This paper shows the scale of global health research and the context in which we frame the
subsequent papers in the Series. In this Series paper, we provide a historical perspective on …

In global health research, short-term, small-scale clinical trials with fixed, two-arm trial
designs that generally do not allow for major changes throughout the trial are the most …

This book will explore the great opportunities and challenges which exist in conducting
clinical trials in developing countries. By exploring the various regulations specific to the …

There is a lot wrong with global health, and the COVID-19 pandemic is highlighting many of
these wrongs. 1 The growing calls to decolonise global health point to imbalances that …

Background Methodological research into the design, conduct, analysis and reporting of
trials is essential to optimise the process. UK specialists in the field have established a set of …

Clinical trials using human subjects are an integral part of the approval of new drugs and
biologics. According to Center Watch, 86% of US clinical studies fail to recruit the required …

Introduction Ideally, health conditions causing the greatest global disease burden should
attract increased research attention. We conducted a comprehensive global study …

COVID-19 has had negative repercussions on the entire global population. Despite there
being a common goal that should have unified resources and efforts, there have been an …

Imagine if the entire edifice of knowledge in medicine was built upon a falsehood.
Systematic reviews are said to be the highest standard of evidence-based health care …

The authors describe key challenges facing the clinical trials community and propose
solutions to these issues, including the role the Clinical Trials Transformation Initiative can …