Purpose: Brain-derived neurotrophic factor (BDNF) is a member of the family of
neurotrophins and promotes diverse effects in neurons including development, maintenance …

Stress activates the hypothalamo–pituitary–adrenal (HPA) axis, regulates the expression of
brain-derived neurotrophic factor (BDNF) in the brain, and mediates mood. Antidepressants …

Ample evidence supports a role of brain-derived neurotrophic factor (BDNF) in the survival
and differentiation of selective populations of neurons in the peripheral and central nervous …

Brain-derived neurotrophic factor (BDNF) is a widely expressed neurotrophin that supports
the survival, differentiation, and signaling of various neuronal populations. Although it has …

The brain-derived neurotrophic factor/tropomyosin receptor kinase B/cAMP response
element-binding protein (BDNF/TrkB/CREB) signaling pathway is a critical therapeutic target …

Stress regulation of brain-derived neurotrophic factor (BDNF) is implicated in the
hippocampal damage observed in depression. BDNF has a complex gene structure with …

Microglia, the resident immune cells of the CNS, have emerged as key regulators of neural
precursor cell activity in the adult brain. However, the microglia-derived factors that mediate …

In the adult mammalian brain, neural stem cells (NSCs) reside in two neurogenic regions,
the walls of the lateral ventricles, and the subgranular zone of the hippocampus, which …

Background: Depression is a mental disorder that poses a serious threat to human health.
Adult hippocampal neurogenesis (AHN) is closely associated with the efficacy of …

BACKGROUND: Because there is evidence that certain neurotrophic factors are involved in
depression and the mechanism of antidepressant treatment, it is hypothesized that …