Interactions between calcium‐induced arrhythmia triggers and the electrophysiological–anatomical substrate underlying the induction of atrial fibrillation
Atrial fibrillation (AF) is the most common cardiac arrhythmia and is sustained by
spontaneous focal excitations and re‐entry. Spontaneous electrical firing in the pulmonary …
spontaneous focal excitations and re‐entry. Spontaneous electrical firing in the pulmonary …
Computational models of atrial cellular electrophysiology and calcium handling, and their role in atrial fibrillation
The complexity of the heart makes an intuitive understanding of the relative contribution of
ion channels, transporters and signalling pathways to cardiac electrophysiology …
ion channels, transporters and signalling pathways to cardiac electrophysiology …
Ionic mechanisms of triggered activity in atrial cell models
Spontaneous electrical activity in the atria, primarily near the pulmonary veins (PVs), is
strongly linked with triggers for atrial fibrillation (AF). However, mechanisms of such …
strongly linked with triggers for atrial fibrillation (AF). However, mechanisms of such …
Intracellular calcium dynamics and atrial fibrillation
Abstract Intracellular Ca 2+(Ca 1) dynamics plays an important role in the initiation and
maintenance of atrial fibrillation (AF). Specific intrinsic action potential properties and …
maintenance of atrial fibrillation (AF). Specific intrinsic action potential properties and …
[HTML][HTML] A novel computational model of the rabbit atrial cardiomyocyte with spatial calcium dynamics
Models of cardiac electrophysiology are widely used to supplement experimental results
and to provide insight into mechanisms of cardiac function and pathology. The rabbit has …
and to provide insight into mechanisms of cardiac function and pathology. The rabbit has …
[HTML][HTML] Arrhythmia mechanisms and spontaneous calcium release: Bi-directional coupling between re-entrant and focal excitation
MA Colman - PLoS computational biology, 2019 - journals.plos.org
Spontaneous sub-cellular calcium release events (SCRE) are conjectured to promote rapid
arrhythmias associated with conditions such as heart failure and atrial fibrillation: they can …
arrhythmias associated with conditions such as heart failure and atrial fibrillation: they can …
[HTML][HTML] Unifying principles of calcium wave propagation—insights from a three-dimensional model for atrial myocytes
Atrial myocytes in a number of species lack transverse tubules. As a consequence the
intracellular calcium signals occurring during each heartbeat exhibit complex spatio …
intracellular calcium signals occurring during each heartbeat exhibit complex spatio …
Evolution and pharmacological modulation of the arrhythmogenic wave dynamics in canine pulmonary vein model
Aims Atrial fibrillation (AF), the commonest cardiac arrhythmia, has been strongly linked with
arrhythmogenic sources near the pulmonary veins (PVs), but underlying mechanisms are …
arrhythmogenic sources near the pulmonary veins (PVs), but underlying mechanisms are …
[HTML][HTML] Persistence of pro-arrhythmic spatio-temporal calcium patterns in atrial myocytes: a computational study of ping waves
Clusters of ryanodine receptors within atrial myocytes are confined to spatially separated
layers. In many species, these layers are not juxtaposed by invaginations of the plasma …
layers. In many species, these layers are not juxtaposed by invaginations of the plasma …
The multidimensional role of calcium in atrial fibrillation pathophysiology: mechanistic insights and therapeutic opportunities
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia, and its prevalence is
increasing with the ageing of the population. Presently available treatment options are far …
increasing with the ageing of the population. Presently available treatment options are far …