Identification of MYC as an antinecroptotic protein that stifles RIPK1–RIPK3 complex formation
The underlying mechanism of necroptosis in relation to cancer is still unclear. Here, MYC, a
potent oncogene, is an antinecroptotic factor that directly suppresses the formation of the …
potent oncogene, is an antinecroptotic factor that directly suppresses the formation of the …
Cytoplasmic MYC is an anti-necroptotic protein
Cancer cells are often resistant to necroptosis as well as apotosis, but the underlying
mechanisms are not fully understood. We recently revealed an important crosstalk between …
mechanisms are not fully understood. We recently revealed an important crosstalk between …
[HTML][HTML] Differential roles of RIPK1 and RIPK3 in TNF-induced necroptosis and chemotherapeutic agent-induced cell death
Apoptosis is a key mechanism for metazoans to eliminate unwanted cells. Resistance to
apoptosis is a hallmark of many cancer cells and a major roadblock to traditional …
apoptosis is a hallmark of many cancer cells and a major roadblock to traditional …
[HTML][HTML] The role of necroptosis: biological relevance and its involvement in cancer
L Della Torre, A Nebbioso, HG Stunnenberg… - Cancers, 2021 - mdpi.com
Simple Summary A new form of programmed necrosis called necroptosis has emerged. This
new and well-documented type of programmed cell death is involved in several human …
new and well-documented type of programmed cell death is involved in several human …
[HTML][HTML] RIPK1 prevents aberrant ZBP1-initiated necroptosis
Receptor interacting protein kinase 1 (RIPK1) regulates inflammation and cell death, in host
defense and homeostasis. The adaptor function of RIPK1 allows pro-survival and …
defense and homeostasis. The adaptor function of RIPK1 allows pro-survival and …
[HTML][HTML] Critical function of the necroptosis adaptor RIPK3 in protecting from intestinal tumorigenesis
D Bozec, AC Iuga, G Roda, S Dahan, G Yeretssian - Oncotarget, 2016 - ncbi.nlm.nih.gov
Necroptosis is a programmed form of non-apoptotic cell death that requires the kinase
activity of the receptor interacting protein kinase 3 (RIPK3). Although in vitro data suggests …
activity of the receptor interacting protein kinase 3 (RIPK3). Although in vitro data suggests …
[HTML][HTML] BRAF and AXL oncogenes drive RIPK3 expression loss in cancer
Necroptosis is a lytic programmed cell death mediated by the RIPK1-RIPK3-MLKL pathway.
The loss of Receptor-interacting serine/threonine-protein kinase 3 (RIPK3) expression and …
The loss of Receptor-interacting serine/threonine-protein kinase 3 (RIPK3) expression and …
RIPK1 can function as an inhibitor rather than an initiator of RIPK3‐dependent necroptosis
Tumour necrosis factor and lipopolysaccharide can promote a regulated form of necrosis,
called necroptosis, upon inhibition of caspase activity in cells expressing receptor …
called necroptosis, upon inhibition of caspase activity in cells expressing receptor …
Complex roles of necroptosis in cancer
F Zhu, W Zhang, T Yang, S He - Journal of Zhejiang University-Science B, 2019 - Springer
Necroptosis is a tightly regulated form of necrosis that requires the activation of receptor-
interacting protein (RIP) kinases RIPK1 and RIPK3, as well as the RIPK3 substrate mixed …
interacting protein (RIP) kinases RIPK1 and RIPK3, as well as the RIPK3 substrate mixed …