Increased ERBB2 Gene Copy Numbers Reveal a Subset of Salivary Duct Carcinomas with High Densities of Tumor Infiltrating Lymphocytes and PD-L1 Expression
K Chatzopoulos, AR Collins, S Sotiriou… - Head and Neck …, 2020 - Springer
Salivary duct carcinoma (SDC) commonly expresses androgen receptor (AR) and HER2,
giving rise to treatment implications. SDC may also express programmed-death-ligand-1 …
giving rise to treatment implications. SDC may also express programmed-death-ligand-1 …
Novel therapeutic targets in salivary duct carcinoma uncovered by comprehensive molecular profiling
SM Gargano, W Senarathne, R Feldman… - Cancer …, 2019 - Wiley Online Library
Salivary duct carcinoma (SDC) is a rare, aggressive salivary gland malignancy, which often
presents at an advanced stage. A proportion of SDC are characterized by HER2 …
presents at an advanced stage. A proportion of SDC are characterized by HER2 …
ERBB2 amplification status in 67 salivary duct carcinomas assessed by immunohistochemistry, fluorescence in situ hybridization, and targeted exome sequencing
DC Ferguson, A Momeni Boroujeni, T Zheng… - Modern …, 2022 - nature.com
Salivary duct carcinoma (SDC) is an aggressive salivary gland malignancy with poor
survival. Approximately 30% SDC harbor HER2 amplification and response to trastuzumab …
survival. Approximately 30% SDC harbor HER2 amplification and response to trastuzumab …
Prognostic markers in salivary gland cancer and their impact on survival
M Szewczyk, A Marszałek, J Sygut, P Golusiński… - Head & …, 2019 - Wiley Online Library
Background The role of molecular markers in salivary gland carcinoma (SGC) is not well
understood. We evaluated molecular marker expression and their prognostic value …
understood. We evaluated molecular marker expression and their prognostic value …
Cytogenetic and immunohistochemical biomarker profiling of therapy‐relevant factors in salivary gland carcinomas
J Lemound, M Schenk, G Keller… - Journal of Oral …, 2016 - Wiley Online Library
Objectives There is currently no established algorithm for the molecular profiling of therapy‐
relevant defects in salivary gland carcinomas (SGC). HER 2 overexpression in a subfraction …
relevant defects in salivary gland carcinomas (SGC). HER 2 overexpression in a subfraction …
Comprehensive molecular profiling of oncocytic salivary gland malignancies
DJ Zaccarini, A Sivapiragasam, E Sokol… - Applied …, 2022 - journals.lww.com
Oncocytic histologic features can be seen in a variety of salivary gland carcinomas. We
performed a comprehensive molecular profiling of 15 salivary gland malignancies with …
performed a comprehensive molecular profiling of 15 salivary gland malignancies with …
Biomarker immunoprofile and molecular characteristics in salivary duct carcinoma: clinicopathological and prognostic implications
T Santana, A Pavel, P Martinek, P Steiner… - Human Pathology, 2019 - Elsevier
Salivary duct carcinoma (SDC) is one of the most aggressive salivary gland tumors, and
prognosis remains poor for most patients. The aim of this study was to investigate the …
prognosis remains poor for most patients. The aim of this study was to investigate the …
ERBB2 amplification and HER2 expression in salivary duct carcinoma: evaluation of scoring guidelines and potential for expanded anti-HER2 therapy
Salivary duct carcinoma (SDC) is aggressive with limited therapeutic options. A subset of
SDC display human epidermal growth factor receptor 2 (HER2) protein overexpression by …
SDC display human epidermal growth factor receptor 2 (HER2) protein overexpression by …
Prognostic significance of biomarkers (c-erbB-2, p53, proliferating cell nuclear antigen, and DNA content) in salivary duct carcinoma
A Felix, AK El-Naggar, MF Press, NG Ordonez… - Human pathology, 1996 - Elsevier
Salivary duct carcinoma (SDC), a rare neoplasm of the major salivary glands, is a high-
grade carcinoma with a predilection for elderly men. The authors investigated the prognostic …
grade carcinoma with a predilection for elderly men. The authors investigated the prognostic …
[HTML][HTML] Molecular patterns in salivary duct carcinoma identify prognostic subgroups
Salivary duct carcinoma (SDCa) is a rare cancer with high rate of metastases and poor
survival despite aggressive multimodality treatment. This study analyzes the genetic …
survival despite aggressive multimodality treatment. This study analyzes the genetic …
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