Current knowledge suggests that hypertension is in part mediated by immune mechanisms.
Both interleukin (IL)-23 and IL-17 are up-regulated in several experimental hypertensive …

Abstract Purpose of Review To summarize key advances in our understanding of the role of
interleukin 17A (IL-17A) in the pathogenesis of hypertension and highlight important areas …

Inflammatory cytokines play a major role in the pathophysiology of hypertension. The
authors previously showed that genetic deletion of interleukin (IL)-17A results in blunted …

We have shown previously that T cells are required for the full development of angiotensin II–
induced hypertension. However, the specific subsets of T cells that are important in this …

Background CD 4+ T helper (Th) cells, including Th1, Th2, and Th17 cells, play critical roles
in angiotensin II–induced hypertension. Th22 cells, a novel subset of Th cells, take part in …

Hypertension is now considered as an inflammatory disease, and the kidney is a key end-
organ target. Experimental and clinical studies suggest that interleukin 17A (IL-17A) is a …

Interestingly, Bellini et al15 recently demonstrated that IL-17A increases proliferation of
fibrocytes, the hematopoietic precursor cells involved in fibrosis16, 17 (Figure). Angiotensin …

T cells participate in angiotensin II (Ang II)–induced hypertension. However, the specific
subsets of T cells that are important in the end-organ damage are unknown. T-helper 17 …

Hypertension, defined as blood pressure greater than 130/80mmHg, affects roughly 1 billion
people worldwide and is the leading cause of cardiovascular disease. 1 As hypertension …

Abstract Interleukin-17A (IL-17A) is a proinflammatory cytokine produced by cells of the
immune system, predominantly Th17 and γδ lymphocytes. In this paper, we review the role …