The kidney is an organ particularly susceptible to damage caused by infections and
autoimmune conditions. Renal inflammation confers protection against microbial infections …

Being a member of the IL-17 family, comprising six structurally related ligands, IL-17A is a
cytokine, produced by multiple cell types, such as CD4+ αβ T cells, γδ T cells, natural killer …

Vascular wall chronic inflammation plays a critical role in the development and progression
of cardiovascular diseases such as atherosclerosis and hypertension. Circulating and tissue …

Chronic kidney injury has gradually become a worldwide public health problem currently
affecting approximately 10% of the population and can eventually progress to chronic end …

Interleukin (IL)-17 is a pro-inflammatory cytokine originally described in T lymphocytes.
Increased production of IL-17 has been linked to the induction of cytokines, chemokines and …

Polarization of naive T cells in a certain functional direction is influenced not only by antigen
type and concentration, but also by co-stimulatory signals, the local cytokine environment …

The IL-17 cytokine family and the cognate receptors thereof have a unique role in organ-
specific autoimmunity. Most studies have focused on the founding member of the IL-17 …

IL-12 and IL-23 are molecules mainly produced by activated accessory and antigen-
presenting cells. The tools for studying the biology of IL-12 in man and laboratory rodents …

Diabetic nephropathy (DN) is the most common cause of ESRD in the United States. Current
standard of care for patients with DN can slow the progression of DN, but there are no …

Inflammatory processes have been shown to play an important role in the mechanisms
involved in the pathogenesis of hypertension. Innate and adaptive immune responses …