Exposure to natural metabolites contributes to the risk of cardiometabolic diseases (CMDs).
Through metabolome profiling, we identify the inverse correlation between serum …

Daily coffee consumption is inversely associated with risk of type-2 diabetes (T2D). Cafestol,
a bioactive substance in coffee, increases glucose-stimulated insulin secretion in vitro and …

Background & aims Hyperglycemia is associated with lipid disorders in patients with
diabetes. Ceramides are metabolites involved in sphingolipid metabolism that accumulate …

Metabolic regulation is inextricably linked with cardiac function. Fatty acid metabolism is a
significant mechanism for creating energy for the heart. However, cardiomyocytes are able …

Hydroxybutyrate (3HB) is a small ketone body molecule produced endogenously by the
body in the liver. Previous studies have shown that 3HB can reduce blood glucose level in …

Afflicting hundreds of millions of individuals globally, diabetes mellitus is a chronic disorder
of energy metabolism characterized by hyperglycemia and other metabolic derangements …

Our previous study demonstrated that long-term cola consumption reduced body weight and
improved insulin sensitivity in healthy male rats. In this study, we investigated the effect and …

Hydroxyderricin (4HD) and xanthoangelol (XAG) are major components of n-hexane/ethyl
acetate (5: 1) extract of the yellow-colored stem juice of Angelica keiskei. 4-Hydroxyderricin …

Chlorogenic acid (CGA) has been shown to stimulate glucose uptake in skeletal muscle
through the activation of AMPK. However, its effect on other metabolic pathways and …

Aim The worldwide increase in obesity and type 2 diabetes (T2D) represents a major health
challenge. Chronically altered lipids induced by obesity further promote the development of …