Very low bilirubin after portoenterostomy improves survival of the native liver in patients with biliary atresia by deferring liver fibrogenesis

M Hukkinen, A Kerola, J Lohi, T Jahnukainen… - Surgery, 2019 - Elsevier
Background Progression of fibrosis and ensuing complications determine the postoperative
course of patients operated on for biliary atresia. We evaluated predictors of the progression …

Treatment policy and liver histopathology predict biliary atresia outcomes: results after national centralization and protocol biopsies

M Hukkinen, A Kerola, J Lohi, P Heikkilä… - Journal of the American …, 2018 - Elsevier
Background Different treatment policies can influence biliary atresia outcomes, but the
pathophysiology of expanding fibrosis occurring even after successful portoenterostomy …

[PDF][PDF] Noninvasive evaluation of liver fibrosis and portal hypertension after successful portoenterostomy for biliary atresia

M Hukkinen, J Lohi, P Heikkilä… - Hepatology …, 2019 - Wiley Online Library
We investigated noninvasive follow‐up markers for histologic liver fibrosis and portal
hypertension (PH) in patients with biliary atresia after successful portoenterostomy (PE) …

Native liver histology after successful portoenterostomy in biliary atresia

H Lampela, S Kosola, P Heikkilä, J Lohi… - Journal of clinical …, 2014 - journals.lww.com
Background: Biliary atresia is the most common indication for childhood liver transplantation.
The effects of successful portoenterostomy (PE) on native liver histology remain unclear …

[PDF][PDF] The limited prognostic value of liver histology in children with biliary atresia

P Czubkowski, J Cielecka-Kuszyk, M Rurarz… - Annals of …, 2016 - medigraphic.com
Background and rationale for the study. The aim of the study was to determine the
prognostic value of histopathological findings with special care to the severity of liver fibrosis …

Molecular signature of active fibrogenesis prevails in biliary atresia after successful portoenterostomy

A Kerola, H Lampela, J Lohi, P Heikkilä, A Mutanen… - Surgery, 2017 - Elsevier
Background In biliary atresia mechanisms of progressive liver injury leading to need of liver
transplantation after successful portoenterostomy remain unknown. A better understanding …

Significance and indications for reoperative portoenterostomy in biliary atresia in light of long‐term outcome

T Saito, K Terui, T Mitsunaga, M Nakata… - Journal of Hepato …, 2018 - Wiley Online Library
Background Among biliary atresia (BA) patients undergoing revision following failed
portoenterostomy, long‐term native liver survival (NLS), physical condition, and indications …

A novel approach to the management of late-onset liver failure in biliary atresia

S Islam, N Dasika, RB Hirschl, AG Coran - Journal of pediatric surgery, 2004 - Elsevier
PURPOSE: Late-onset hyperbilirubinemia in patients who have undergone a successful
portoenterostomy (PE) for biliary atresia (BA) is usually considered evidence of ongoing …

Bilirubin level 1 week after hepatoportoenterostomy predicts native liver survival in biliary atresia

CY Huang, MH Chang, HL Chen, YH Ni, HY Hsu… - Pediatric …, 2020 - nature.com
Background To determine a very early predictive biomarker after hepatoportoenterostomy
(HPE) for the prediction of native liver survival in biliary atresia (BA) patients. Methods A …

The extent of biliary proliferation in liver biopsies from patients with biliary atresia at portoenterostomy is associated with the postoperative prognosis

JL Santos, CO Kieling, L Meurer, S Vieira… - Journal of Pediatric …, 2009 - Elsevier
BACKGROUND/PURPOSE: In biliary atresia (BA), a derangement in the biliary system
remains, despite portoenterostomy performance. Many factors can influence the disease …