Developing immature follicles either from fresh or cryopreserved ovarian tissue to attain
competent and fertilisable oocytes could provide an option for some patients undergoing …

The preservation of genome integrity in the mammalian female germline from primordial
follicle arrest to activation of growth to oocyte maturation is fundamental to ensure …

In the mammalian ovary a small number of follicles are steadily recruited from the quiescent
pool to undergo development. Follicle loss, maintenance and growth are strictly controlled …

The mammalian ovary has two main functions—producing mature oocytes for fertilization
and secreting hormones for maintaining the ovarian endocrine functions. Both functions are …

Immature ovarian primordial follicles are essential for maintenance of the reproductive
lifespan of female mammals. Recently, it was found that overactivation of the …

In this study, we explored the effects of oocytic phosphoinositide 3-kinase (PI3K) activation
on folliculogensis by generating transgenic mice, in which the oocyte-specific Cre …

Cryopreservation and transplantation of ovarian tissue represent a promising fertility
preservation technique for prepubertal patients or for patients requiring urgent oncological …

Objective While fate of ovarian failure after chemotherapy has been well established, the
precise mechanism by which this occurs is less clear. Recent study has revealed that …

The ovarian follicles develop initially from primordial follicles. The majority of ovarian
primordial follicles are maintained quiescently as a reserve for the reproductive life span …

In vitro folliculogenesis of primordial and early preantral follicles is necessary for increment
of reproductive efficiency in domestic animals, humans and endangered species. Recent …