Age-related changes in social behaviours in the 5xFAD mouse model of Alzheimer's disease

F Kosel, PT Munoz, JR Yang, AA Wong… - Behavioural Brain …, 2019 - Elsevier
In addition to memory impairments, patients with Alzheimer's disease (AD) exhibit a number
of behavioural and psychological symptoms that can affect social interactions over the …

Reduced social investigation and increased injurious behavior in transgenic 5xFAD mice

F Kosel, JS Hamilton, SL Harrison… - Journal of …, 2021 - Wiley Online Library
Social withdrawal and agitation/aggression are common behavioral and psychological
symptoms of dementia presented by Alzheimer's disease (AD) patients, with males …

Sex differences in behavior and molecular pathology in the 5XFAD model

A Sil, A Erfani, N Lamb, R Copland… - Journal of …, 2022 - content.iospress.com
Background: The prevalence of Alzheimer's disease (AD) is greater in women compared to
men, but the reasons for this remain unknown. This sex difference has been widely …

Behavioral and EEG changes in male 5xFAD mice

F Schneider, K Baldauf, W Wetzel, KG Reymann - Physiology & behavior, 2014 - Elsevier
Transgenic animal models of Alzheimer's disease (AD) are widely used to investigate
mechanisms of pathophysiology and cognitive dysfunctions. A model with a very early …

Sex-dependent alterations in social behaviour and cortical synaptic activity coincide at different ages in a model of Alzheimer's disease

C Bories, MJ Guitton, C Julien, C Tremblay, M Vandal… - 2012 - journals.plos.org
Besides memory deficits, Alzheimer's disease (AD) patients suffer from neuropsychiatric
symptoms, including alterations in social interactions, which are subject of a growing …

Limited impact of social isolation on Alzheimer-like symptoms in a triple transgenic mouse model.

S Pietropaolo, Y Sun, R Li, C Brana… - Behavioral …, 2009 - psycnet.apa.org
Gene-environment interactions are known to play a major role in the ethiopathology of
several neuropsychiatric disorders, including Alzheimer's disease (AD). The present study …

[HTML][HTML] Epigenetic mechanisms underlying cognitive impairment and Alzheimer disease hallmarks in 5XFAD mice

C Griñán-Ferré, S Sarroca, A Ivanova… - Aging (Albany …, 2016 - ncbi.nlm.nih.gov
Abstract 5XFAD is an early-onset mouse transgenic model of Alzheimer disease (AD). Up to
now there are no studies that focus on the epigenetic changes produced as a result of Aβ-42 …

Intact olfactory memory in the 5xFAD mouse model of Alzheimer's disease from 3 to 15 months of age

TP O'leary, KR Stover, HM Mantolino, S Darvesh… - Behavioural brain …, 2020 - Elsevier
Alzheimer's disease (AD) is an age-related neurodegenerative disorder that causes
profound cognitive dysfunction. Deficits in olfactory memory occur in early stages of AD and …

Characterization of apathy-like behaviors in the 5xFAD mouse model of Alzheimer's disease

R Keszycki, G Rodriguez, JT Dunn, A Locci… - Neurobiology of …, 2023 - Elsevier
Most patients with Alzheimer's disease (AD) develop neuropsychiatric symptoms (NPS)
alongside cognitive decline, and apathy is one of the most common symptoms. Few …

Vibrating tail, digging, body/face interaction, and lack of barbering: sex-dependent behavioral signatures of social dysfunction in 3xTg-AD mice as compared to mice …

V Torres-Lista, L Giménez-Llort - Journal of Alzheimer's …, 2019 - content.iospress.com
Modeling of Alzheimer's disease (AD), classically focused on the subject-environment
interaction, foresees current social neuroscience efforts as improving the predictive validity …