Among the challenges to the 21st-century health care industry, one that demands special
mention is the transport of drugs/active pharmaceutical agents across the blood–brain …

The ability to target specific cell types to achieve optimal distribution of therapeutic entities
into diseased tissues, while limiting possible adverse off-target effects, has long been a goal …

The hydrophilic nature of peptides and proteins renders them impermeable to cell
membranes. Thus, in order to successfully deliver peptide and protein-based therapeutics …

The blood-brain barrier (BBB), a dynamic and complex barrier formed by endothelial cells,
can impede the entry of unwanted substances–pathogens and therapeutic molecules alike …

Nearly one in six people worldwide suffer from disorders of the central nervous system
(CNS). There is an urgent need for effective strategies to improve the success rates in CNS …

The passage of therapeutic molecules across the Blood-Brain Barrier (BBB) is a profound
challenge for the management of the Central Nervous System (CNS)-related diseases. The …

“Cell-penetrating peptides (CPPs)” is an inclusive term describing relatively small peptides
(6− 30 amino acid residues) having membrane translocation activity. Due to their efficacy in …

Simple Summary Crossing biological barriers is often required for drug delivery. Cell-
penetrating peptides (CPPs) are short strands of amino acids that have been widely used as …

The challenge of effectively delivering therapeutic agents to brain has led to an entire field of
active research devoted to overcome the blood brain barrier (BBB) and efficiently deliver …

Peptides and proteins, two important classes of biomacromolecules, play important roles in
the biopharmaceuticals field. As compared with traditional drugs based on small molecules …