The C. elegans insulin/IGF-1 signaling (IIS) pathway connects nutrient levels to metabolism,
growth, development, longevity, and behavior. This fundamental pathway is regulated by …

In a remarkably conserved insulin signaling pathway that is well‐known for its regulation of
longevity in worms, flies, and mammals, the major C. elegans effector of this pathway, DAF …

Modulation of insulin/IGF signaling in the nematode Caenorhabditis elegans is the central
determinant of the endocrine control of stress response, diapause, and aging. Mutations in …

An insulin-like signaling pathway regulates development and lifespan in Caenorhabditis
elegans. Genetic screens that identified many components of the C. elegansinsulin pathway …

The C. elegans insulin/IGF-1 signaling (IIS) cascade plays a central role in regulating life
span, dauer, metabolism, and stress. The major regulatory control of IIS is through …

The insulin/insulin‐like growth factor‐like signaling (IIS) pathway in metazoans has
evolutionarily conserved roles in growth control, metabolic homeostasis, stress responses …

Cell proliferation must be coordinated with cell fate specification during development, yet
interactions among pathways that control these two critical aspects of development are not …

Insulin/insulin-like growth factor signalling (IIS) is a critical regulator of an organism's most
important biological decisions from growth, development, and metabolism to reproduction …

Mutations in the daf‐2 gene of the conserved Insulin/Insulin‐like Growth Factor (IGF‐1)
pathway double the lifespan of the nematode Caenorhabditis elegans. This phenotype is …

Insulin/IGF‐1 signaling controls metabolism, stress resistance and aging in Caenorhabditis
elegans by regulating the activity of the DAF‐16/FoxO transcription factor (TF). However, the …