The genetic toxicity of methylphenidate: a review of the current literature
SM Morris, DM Petibone, WJ Lin… - Journal of Applied …, 2012 - Wiley Online Library
Attention deficit/hyperactivity disorder (ADHD), a common children's behavioral disorder, is
characterized by inattention, hyperactivity and impulsivity. The disorder is thought to stem …
characterized by inattention, hyperactivity and impulsivity. The disorder is thought to stem …
Prospective follow-up studies found no chromosomal mutagenicity of methylphenidate therapy in ADHD affected children
S Walitza, K Kämpf, RG Oli, A Warnke, M Gerlach… - Toxicology letters, 2010 - Elsevier
Five to ten percent of all children suffer from attention-deficit/hyperactivity disorder (ADHD),
which is often treated with the central nervous stimulant methylphenidate (MPH). In 2005 …
which is often treated with the central nervous stimulant methylphenidate (MPH). In 2005 …
Cytogenetic assessment of methylphenidate treatment in pediatric patients treated for attention deficit hyperactivity disorder
JD Tucker, W Suter, DM Petibone, RA Thomas… - … /Genetic Toxicology and …, 2009 - Elsevier
Methylphenidate (MPH, Ritalin®), has been prescribed to treat attention deficit/hyperactivity
disorder (ADHD) since its approval by the FDA over 50 years ago. Diagnoses of pediatric …
disorder (ADHD) since its approval by the FDA over 50 years ago. Diagnoses of pediatric …
No elevated genomic damage in children and adolescents with attention deficit/hyperactivity disorder after methylphenidate therapy
BACKGROUND AND OBJECTIVE: Attention-deficit/hyperactivity disorder (ADHD) is the
most frequent psychiatric disorder in children and adolescents and is often treated with …
most frequent psychiatric disorder in children and adolescents and is often treated with …
Brief review of available evidence concerning the potential induction of genomic damage by methylphenidate
H Stopper, S Walitza, A Warnke, M Gerlach - Journal of Neural …, 2008 - Springer
Children affected by attention deficit/hyperactivity disorder are often treated with
methylphenidate (MPH). Two years ago, an increase in genomic damage after 3 months of …
methylphenidate (MPH). Two years ago, an increase in genomic damage after 3 months of …
Does methylphenidate cause a cytogenetic effect in children with attention deficit hyperactivity disorder?
Background and objective Attention deficit hyperactivity disorder (ADHD) is the most
common psychiatric disorder in children and adolescents (6–12% affected). Treatment with …
common psychiatric disorder in children and adolescents (6–12% affected). Treatment with …
Absence of cytogenetic effects in children and adults with attention-deficit/hyperactivity disorder treated with methylphenidate
I Ponsa, JA Ramos-Quiroga, M Ribasés… - Mutation Research …, 2009 - Elsevier
Attention-deficit/hyperactivity disorder (ADHD) is the most common psychiatric condition with
onset in childhood, and in more than 50% of cases it persists into adulthood as a chronic …
onset in childhood, and in more than 50% of cases it persists into adulthood as a chronic …
No increases in biomarkers of genetic damage or pathological changes in heart and brain tissues in male rats administered methylphenidate hydrochloride (Ritalin) …
KL Witt, DE Malarkey, CA Hobbs… - Environmental and …, 2010 - Wiley Online Library
Following a 2005 report of chromosomal damage in children with attention
deficit/hyperactivity disorder (ADHD) who were treated with the commonly prescribed …
deficit/hyperactivity disorder (ADHD) who were treated with the commonly prescribed …
D-Methylphenidate is non-genotoxic in in vitro and in vivo assays
SK Teo, RH San, VO Wagner, R Gudi, DI Stirling… - … /Genetic Toxicology and …, 2003 - Elsevier
d-Methylphenidate (dexmethylphenidate; d-MPH) and its racemate d, l-methylphenidate (d, l-
MPH) are currently prescribed for the chronic treatment of attention deficit hyperactivity …
MPH) are currently prescribed for the chronic treatment of attention deficit hyperactivity …
Specific genes associated with adverse events of methylphenidate use in the pediatric population: a systematic literature review
The aim of this study was to review empirical studies examining associations between
candidate genes and adverse events (AEs) from methylphenidate (MPH) use in children and …
candidate genes and adverse events (AEs) from methylphenidate (MPH) use in children and …