Background Cerebrospinal fluid (CSF) lactate levels have been suggested to be associated
with disease severity and progression in several neurological diseases as an indicator of …

Objectives To investigate, in patients with Alzheimer's Disease (AD), the possible interplay
linking alteration of neuronal energy metabolism, as measured via cerebrospinal fluid (CSF) …

Background Altered cerebrospinal fluid (CSF) levels of lactate have been described in
neurodegenerative diseases and related to mitochondrial dysfunction and neuronal …

Mitochondrial dysfunction is pivotal in the development of neurodegenerative dementias,
causing cellular death alongside disease-specific pathogenic cascades. Holding …

Background The cerebrospinal fluid (CSF)/serum albumin quotient (Q-Alb) is a marker of the
blood-CSF barrier (BCSFB) and possibly of the blood–brain barrier (BBB). The latter is …

Background: Previous studies have shown an association between disruption of the blood-
brain-barrier (BBB) and dementias of different etiologies. The protein concentration of …

Despite recent studies examining the association between neurodegenerative diseases and
mitochondrial dysfunction, there are not sufficient data on factors that influence …

Background Alterations in the CSF/serum albumin ratio (Qalb) is currently recognized as
one of the most reliable markers of blood–brain barrier impairment and blood-CSF barrier …

Mild cognitive impairment (MCI) is a well-established prodromal stage of dementia (eg,
Alzheimer's disease) that is often accompanied by early signs of neurodegeneration. To …

Background: Neuropathologically, Alzheimer's disease (AD) is characterized by
accumulation of a 42 amino acid peptide called amyloid-β (Aβ 42) in extracellular senile …