The structural nuclear proteins known as “lamins”(A-type and B-type) provide a scaffold for
the compartmentalization of genome function that is important to maintain genome stability …

Hutchinson-Gilford progeria syndrome (HGPS) is a premature aging condition that involves
genetic mutations, resulting in debilitating phenotypic features. The present state of …

Products of the LMNA gene, primarily lamin A and C, are key components of the nuclear
lamina, a proteinaceous meshwork that underlies the inner nuclear membrane and is …

In the last decade, we have seen increasing evidence of the importance of structural nuclear
proteins such as lamins in nuclear architecture and compartmentalization of genome …

Hutchinson–Gilford progeria syndrome (HGPS) is an extremely rare premature aging
disease presenting many features resembling the normal aging process. HGPS patients die …

Hutchinson-Gilford progeria syndrome (HGPS) is a sporadic, autosomal dominant disorder
characterized by premature and accelerated aging symptoms leading to death at the mean …

Hutchinson-Gilford progeria syndrome (HGPS) is a lethal genetic disorder characterized by
premature aging. HGPS is most commonly caused by a de novo single-nucleotide …

In humans, aging is characterized by a gradual decline of physical and psychological
functions, with the concomitant onset of chronic-degenerative diseases, which ultimately …

Lamins are nuclear intermediate filaments. In addition to their structural roles, they are
implicated in basic nuclear functions such as chromatin organization, DNA replication …

The metazoan nucleus is equipped with a meshwork of intermediate filament proteins called
the A-and B-type lamins. Lamins lie beneath the inner nuclear membrane and serve as a …