The kidney contains receptors for the cytokine IL-25, but the effects of IL-25 in CKD are
unknown. Here, we induced adriamycin nephropathy in both BALB/c mice and severe …

IL-25 is an important immune regulator that can promote Th2 immune response-dependent
immunity, inflammation, and tissue repair in asthma, intestinal infection, and autoimmune …

IL-15, a T cell growth factor, has been linked to exacerbating autoimmune diseases and
allograft rejection. To test the hypothesis that IL-15–deficient (IL-15–/–) mice would be …

Interleukin (IL)-10 is an anti-inflammatory factor that suppresses renal fibrosis and improves
renal function in CKD rats. IL-20 belongs to the IL-10 family; therefore, we sought to …

Despite its initially defined role as a T-helper type 1 cell (Th1)–inducing cytokine, interleukin-
27 (IL-27) has complex roles in vivo. The role of IL-27 receptor (IL-27R) was defined in …

Clinical and experimental studies have established that immune cells such as alternatively
activated (M2) macrophages and Th17 cells play a role in the progression of chronic kidney …

T helper (Th) 17 cells might contribute to immune-mediated renal injury. Thus, we sought to
define the time course of IL-17A-induced kidney damage and examined the relation …

Interstitial kidney inflammation is present in various nephritides in which serum interleukin
23 (IL-23) is elevated. Here we showed that murine and human renal tubular epithelial cells …

Adriamycin nephropathy (AN) is an experimental model of focal segmental
glomerulosclerosis (FSGS) in which macrophages are considered to play a pathogenic role …

T cells infiltrate the kidney in both human and experimental glomerulonephritis, and several
lines of evidence indicate that T cell-mediated tissue damage plays an important role in the …