Angiogenesis, the sprouting of new blood vessels from existing vessels, is one of six known
mechanisms employed by solid tumors to recruit blood vessels necessary for their initiation …

Vascular endothelial growth factor (VEGF) is the term used for a family of tumor-derived
angiogenic factors that mediate endothelial proliferation and vascular permeability …

Purpose: Vascular endothelial growth factor (VEGF) signaling is key to tumor angiogenesis
and is an important target in the development of anticancer drugs. However, VEGF receptor …

Tumors induce angiogenesis to acquire oxygen and nutrition from their adjacent
microenvironment. Tumor angiogenesis has been believed to be induced primarily by the …

Tumors exploit angiogenesis, the formation of new blood vessels from pre-existing
vasculature, in order to obtain nutrients required for continued growth and proliferation …

Vascular endothelial growth factor A (VEGF-A or VEGF) is a highly conserved secreted
signalling protein best known for its roles in vascular development and angiogenesis. Many …

Angiogenesis, the formation of new blood vessels from existing vessels, is required for tumor
growth, proliferation, and metastasis. Vascular endothelial growth factor (VEGF) is a key …

A major obstacle compromising the successful application of many of the new targeted
anticancer drugs, including angiogenesis inhibitors, is the empiricism associated with …

Vascular endothelial growth factor A (VEGF-A) and its cognate receptors are central to the
regulation of angiogenesis in both physiological and pathological states. In cancer, local …

Angiogenesis plays a critical role in several physiologic and pathologic processes,
particularly in tumor growth, invasion, and metastasis (1). New blood vessels provide tumors …