Disentangling and quantifying the relative cognitive impact of concurrent mixed neurodegenerative pathologies
Neurodegenerative pathologies such as Alzheimer disease neuropathologic change
(ADNC), Lewy body disease (LBD), limbic-predominant age-related TDP-43 …
(ADNC), Lewy body disease (LBD), limbic-predominant age-related TDP-43 …
Cognitive resistance to and resilience against multiple comorbid neurodegenerative pathologies and the impact of APOE status
JM Walker, TE Richardson - Journal of Neuropathology & …, 2023 - academic.oup.com
Alzheimer disease (AD) is currently the leading cause of cognitive decline and dementia
worldwide. Recently, studies have suggested that other neurodegenerative comorbidities …
worldwide. Recently, studies have suggested that other neurodegenerative comorbidities …
Mixed neuropathologies and associations with domain-specific cognitive decline
Objective: To test whether decline in specific cognitive domains associated with Alzheimer
disease neuropathologic change (ADNC) is modified by co-occurrence of other …
disease neuropathologic change (ADNC) is modified by co-occurrence of other …
Person‐specific contribution of neuropathologies to cognitive loss in old age
Objective Mixed neuropathologies are the most common cause of dementia at the
population level, but how different neuropathologies contribute to cognitive decline at the …
population level, but how different neuropathologies contribute to cognitive decline at the …
Cognitive symptoms progress with limbic-predominant age-related TDP-43 encephalopathy stage and co-occurrence with Alzheimer disease
S Hiya, C Maldonado-Díaz, JM Walker… - … of Neuropathology & …, 2024 - academic.oup.com
Limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-
NC) is a neuropathologic entity characterized by transactive response DNA-binding protein …
NC) is a neuropathologic entity characterized by transactive response DNA-binding protein …
Comorbid neuropathological diagnoses in early versus late-onset Alzheimer's disease
Co-pathologies play an important role in the expression of the Alzheimer's disease clinical
phenotype and may influence treatment efficacy. Early-onset Alzheimer's disease, defined …
phenotype and may influence treatment efficacy. Early-onset Alzheimer's disease, defined …
Association of TDP-43 proteinopathy, cerebral amyloid angiopathy, and Lewy bodies with cognitive impairment in individuals with or without Alzheimer's disease …
Alzheimer's disease patients typically present with multiple co-morbid neuropathologies at
autopsy, but the impact of these pathologies on cognitive impairment during life is poorly …
autopsy, but the impact of these pathologies on cognitive impairment during life is poorly …
Concomitant neurodegenerative pathologies contribute to the transition from mild cognitive impairment to dementia
Introduction The aged brain frequently exhibits multiple pathologies, rather than a single
hallmark pathology (pure pathology [PurP]), ranging from low/intermediate levels of …
hallmark pathology (pure pathology [PurP]), ranging from low/intermediate levels of …
Mixed neuropathologies and estimated rates of clinical progression in a large autopsy sample
WD Brenowitz, RA Hubbard, CD Keene… - Alzheimer's & …, 2017 - Elsevier
Introduction Whether co-occurring neuropathologies interact or independently affect clinical
disease progression is uncertain. We estimated rates of clinical progression and tested …
disease progression is uncertain. We estimated rates of clinical progression and tested …
Frequency of LATE neuropathologic change across the spectrum of Alzheimer's disease neuropathology: Combined data from 13 community-based or population …
Limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-
NC) and Alzheimer's disease neuropathologic change (ADNC) are each associated with …
NC) and Alzheimer's disease neuropathologic change (ADNC) are each associated with …