CD8+ T cells outnumber CD4+ cells in multiple sclerosis (MS) lesions associated with
disease progression, but the pathogenic role and antigenic targets of these clonally …

Multiple sclerosis (MS) is an inflammatory disease of the CNS thought to be driven by CNS-
specific T lymphocytes. Although CD8+ T cells are frequently found in multiple sclerosis …

Multiple sclerosis (MS) is an inflammatory, demyelinating disease of the central nervous
system (CNS). MS is thought to be T-cell-mediated, with prior research predominantly …

Myelin-specific CD8+ T cells are thought to contribute to the pathogenesis of multiple
sclerosis. Here we modeled this contribution in mice with CD8+ T cells recognizing …

Patients with multiple sclerosis (MS) show a high prevalence of myelin-reactive CD8+ and
CD4+ T-cell responses, which are the putative effectors/modulators of CNS neuropathology …

Multiple sclerosis (MS) is an inflammatory, demyelinating disease of the CNS. Although
CD4+ T cells are implicated in MS pathogenesis and have been the main focus of MS …

Axon injury is a central determinant of irreversible neurological deficit and disease
progression in patients with multiple sclerosis (MS). CD8+ lymphocytes (CTLs) within …

CD8 T cells are emerging as important players in multiple sclerosis (MS) pathogenesis,
although their direct contribution to tissue damage is still debated. To assess whether …

Polyspecific T cells recognizing multiple distinct self-antigens have been identified in
multiple sclerosis and other organ-specific autoimmune diseases, but their …

Multiple sclerosis (MS) is a demyelinating disease of the central nervous system (CNS)
characterized by plaques of infiltrating CD4+ and CD8+ T cells. Studies of MS and …