Interleukin-6 supplementation improves bovine conceptus elongation and transcriptomic indicators of developmental competence

SL Speckhart, MA Oliver, JA Keane… - Biology of …, 2024 - academic.oup.com
A high incidence of pregnancy failures occurs in cattle during the second week of pregnancy
as blastocysts transition into an elongated conceptus. This work explored whether …

Interleukin-6 supplementation improves post-transfer embryonic and fetal development of in vitro-produced bovine embryos

ZK Seekford, LK Wooldridge, NW Dias, CL Timlin… - Theriogenology, 2021 - Elsevier
The use of in vitro produced embryos in dairy and beef cattle has increased in recent years,
but compromised post-transfer pregnancy success prevents producers from capturing all the …

[HTML][HTML] Cytokines that serve as embryokines in cattle

AD Ealy, SL Speckhart, LK Wooldridge - Animals, 2021 - mdpi.com
Simple Summary This review will explore how some cytokines also influence early
embryonic development. We term these types of molecules as embryokines. Understanding …

298 Interleukin-6 family members improve Pre-Implantation bovine blastocyst composition

MA Oliver, SL Speckhart, A Ealy - Journal of Animal Science, 2023 - academic.oup.com
Inner cell mass (ICM) size is a predictor of bovine blastocyst quality and post-transfer
pregnancy success. In vitro produced (IVP) embryos have reduced ICM cell numbers …

[HTML][HTML] Interleukin-6 increases inner cell mass numbers in bovine embryos

LK Wooldridge, AD Ealy - BMC developmental biology, 2019 - Springer
Background Work in other species suggests that interleukin-6 (IL6) promotes early embryo
development. It was unclear whether IL6 serves as an embryokine in cultured bovine …

Interleukin-6 stimulates in vitro development of late-stage ovine embryos

PK Javvaji, JR Francis, A Dhali, AP Kolte… - Journal of Reproductive …, 2023 - Elsevier
The effect of interleukin-6 (IL-6) supplementation during the different phases of in vitro
embryo culturing (IVC) on embryo development and embryonic gene expression was …

[HTML][HTML] Influences of Supplementing Selective Members of the Interleukin-6 Cytokine Family on Bovine Oocyte Competency

E McKinley, SL Speckhart, JA Keane, MA Oliver… - Animals, 2023 - mdpi.com
Simple Summary In vitro-produced (IVP) bovine embryos have reduced developmental
potential and post-transfer survival. One reason this may occur is because of the lack of …

Interleukin-6 requires JAK to stimulate inner cell mass expansion in bovine embryos

LK Wooldridge, SE Johnson, RR Cockrum… - …, 2019 - rep.bioscientifica.com
Supplementing interleukin-6 (IL6) to in vitro-produced bovine embryos increases inner cell
mass (ICM) cell numbers in blastocysts. A series of studies were completed to further dissect …

[HTML][HTML] Interleukin-7 enhances in vitro development and blastocyst quality in porcine parthenogenetic embryos

D Oh, H Choi, M Kim, L Cai, J Lee, A Jawad… - Frontiers in Veterinary …, 2022 - frontiersin.org
Interleukin-7 (IL-7), a vital factor that affects cell development, proliferation, and survival,
plays an important role in oocyte maturation. However, its role in embryonic development …

[HTML][HTML] Interleukin-6 promotes primitive endoderm development in bovine blastocysts

LK Wooldridge, AD Ealy - BMC Developmental Biology, 2021 - Springer
Abstract Background Interleukin-6 (IL6) was recently identified as an embryotrophic factor in
bovine embryos, where it acts primarily to mediate inner cell mass (ICM) size. This work …