The involvement of the ERK-MAPK pathway in TGF-β1–mediated connexin43-gap junction formation in chondrocytes

Q Wang, C Zhou, D Zhang, J Zou, W Liu… - Connective Tissue …, 2019 - Taylor & Francis
Purposes: Gap junction intercellular communication (GJIC) exhibits a key role in maintaining
the homeostasis of articular cartilage. Connexin43 (Cx43) protein is predominant in the …

[HTML][HTML] TGF-β2 increases cell-cell communication in chondrocytes via p-Smad3 signalling

M Duan, Y Liu, D Guo, S Kan, Z Niu, X Pu, M Bai… - … et Biophysica Acta (BBA …, 2022 - Elsevier
Abstract Connexin 43 (Cx43)-mediated gap junction intercellular communication (GJIC)
plays a crucial role in the pathology and physiology of joint tissues. Transforming growth …

TGF-β3 enhances cell-to-cell communication in chondrocytes via the ALK5/p-Smad3 axis

L Cai, C Pi, D Guo, J Li, H Chen, D Zhang… - Biochemical and …, 2022 - Elsevier
Gap junctional intercellular communication (GJIC) is indispensable for the maintenance of
physiological balance in articular cartilage. Transforming growth factor-β3 (TGF-β3), an …

TGF‐β1 promotes gap junctions formation in chondrocytes via Smad3/Smad4 signalling

Q Wang, C Zhou, X Li, L Cai, J Zou, D Zhang… - Cell …, 2019 - Wiley Online Library
Objectives Connexin‐mediated functional gap junction intercellular communication (GJIC)
has a vital role in development, homeostasis and pathology. Transforming growth factor‐β1 …

CTGF facilitates cell‐cell communication in chondrocytes via PI3K/Akt signalling pathway

Z Wu, C Zhou, Q Yuan, D Zhang, J Xie… - Cell proliferation, 2021 - Wiley Online Library
Purposes Gap junction intercellular communication (GJIC) is essential for articular cartilage
to respond appropriately to physical or biological stimuli and maintain homeostasis …

Fibroblast growth factor 8 facilitates cell-cell communication in chondrocytes via p38-MAPK signaling

X Cao, L Cai, D Guo, D Zhang, X Zhou, J Xie - Tissue and Cell, 2023 - Elsevier
Gap junction intercellular communication (GJIC) is essential for regulating the development
of the organism and sustaining the internal environmental homeostasis of multi-cellular …

Articular chondrocyte network mediated by gap junctions: role in metabolic cartilage homeostasis

MD Mayan, R Gago-Fuentes… - Annals of the …, 2015 - ard.bmj.com
Objective This study investigated whether chondrocytes within the cartilage matrix have the
capacity to communicate through intercellular connections mediated by voltage-gated gap …

PDGF-AA promotes gap junction intercellular communication in chondrocytes via the PI3K/Akt pathway

S Xu, Y Liu, D Zhang, H Huang, J Li, J Wei… - Connective Tissue …, 2022 - Taylor & Francis
Background Gap junction intercellular communication (GJIC) plays an important role in cell
growth, development and homeostasis. Connexin 43 (Cx43) is an important half-channel …

Transforming growth factor-β1 up-regulates connexin43 expression in osteocytes via canonical Smad-dependent signaling pathway

W Liu, Y Cui, J Sun, L Cai, J Xie, X Zhou - Bioscience reports, 2018 - portlandpress.com
Connexin 43 (Cx43)-mediated gap junctional intercellular communication (GJIC) has been
shown to be important in regulating multiple functions of bone cells. Transforming growth …

[HTML][HTML] Biochemical evidence for gap junctions and Cx43 expression in immortalized human chondrocyte cell line: a potential model in the study of cell …

R Gago-Fuentes, P Carpintero-Fernandez… - Osteoarthritis and …, 2014 - Elsevier
Objective The development of chondrocytic cell lines has enabled the investigation of the
role of cellular phenotype and mechanisms in articular cartilage biology and …