Background The intracellular ROCK signaling pathway is an important modulator of blood
pressure and of cardiovascular and renal remodeling when Rho-kinase activity is increased …

Background Accumulating evidence indicates that Rho-associated kinase (ROCK) has been
involved in the pathogenesis of insulin resistance and diabetes. However, little clinical …

Background: Few clinical studies have assessed Rho kinase (ROCK) in patients with
diabetes mellitus (DM) and ST-segment elevation myocardial infarction (STEMI). This study …

RhoA/Rho kinase: a novel therapeutic target in diabetic comp... : Chinese Medical Journal
RhoA/Rho kinase: a novel therapeutic target in diabetic complications : Chinese Medical Journal …

Abstract Objectives Activation of RhoA/Rho-kinase (ROCK) is increasingly implicated in
acute vasospasm and chronic vasoconstriction in major organ systems. Therefore we aimed …

The small GTPase RhoA and its downstream effector, Rho kinase (ROCK), appear to
mediate numerous pathophysiological signals, including smooth muscle cell contraction …

Objectives The RhoA/ROCK pathway contributes to diabetic cardiomyopathy in part by
promoting the sustained activation of PKCβ2 but the details of their interaction are unclear …

Diabetic nephropathy is a public health problem worldwide. Our understanding of the
molecular machinery, as well as the clinical therapies for diabetic nephropathy, has evolved …

Rho-associated kinases ROCK1 and ROCK2 are serine/threonine kinases that are
downstream targets of the small GTPases RhoA, RhoB, and RhoC. ROCKs are involved in …

Despite remaining questions in this field, such as the specificity of currently available
ROCKi, or the roles of individual ROCK isoforms, recent evidence in experimental diabetes …