Multiple sclerosis (MS) has long been considered a CD4 T-cell disease, primarily because
of the findings that the strongest genetic risk for MS is the major histocompatibility complex …

Our understanding of the pathophysiology of multiple sclerosis (MS) has evolved
significantly over the past two decades as the fields of immunology and neurobiology …

Multiple sclerosis (MS) is a demyelinating inflammatory disorder of the central nervous
system (CNS), which involves autoimmune responses to myelin antigens. Studies in …

Introduction: CD8+ T cells were originally considered to exert a suppressive role in
demyelinating disease because of bias toward the CD4+ T cell-mediated experimental …

T lymphocytes play a central role in the pathogenesis of multiple sclerosis (MS)(Zhang et al.,
1992). Both CD4+ and CD8+ T cells have been demonstrated in MS lesions, with CD4+ T …

Introduction Multiple sclerosis (MS) is a complex genetic disease characterized by chronic
inflammation of the central nervous system (CNS). The pathology of MS is largely attributed …

A growing body of evidence suggests that autoreactive CD8 T cells contribute to the disease
process in multiple sclerosis (MS). Lymphocytes in MS plaques are biased toward the CD8 …

Multiple sclerosis (MS) is an inflammatory disease in which the myelin sheaths around the
axons of the brain and spinal cord are damaged, leading to demyelination and scarring as …

The role of CD8+ T cells in multiple sclerosis (MS) and its animal models has been
enigmatic. Most studies of MS have focused on the role of CD4+ Th1 T cells and many …

Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system
characterized by focal demyelination patches associated with inflammatory infiltrates …