[HTML][HTML] Expression-and splicing-based multi-tissue transcriptome-wide association studies identified multiple genes for breast cancer by estrogen-receptor status

JC McClellan, JL Li, G Gao, D Huo - Breast Cancer Research, 2024 - Springer
Background Although several transcriptome-wide association studies (TWASs) have been
performed to identify genes associated with overall breast cancer (BC) risk, only a few TWAS …

[HTML][HTML] Sex steroid hormones and risk of breast cancer: a two-sample Mendelian randomization study

A Nounu, SP Kar, CL Relton, RC Richmond - Breast Cancer Research, 2022 - Springer
Background Breast cancer (BC) has the highest cancer incidence and mortality in women
worldwide. Observational epidemiological studies suggest a positive association between …

[HTML][HTML] Breast cancer incidence in black and white women stratified by estrogen and progesterone receptor statuses

MX Gleason, T Mdzinarishvili, S Sherman - PLoS One, 2012 - journals.plos.org
Background There is increasing evidence that breast cancer is a heterogeneous disease
presented by different phenotypes and that white women have a higher breast cancer …

The magnitude of androgen receptor positivity in breast cancer is critical for reliable prediction of disease outcome

C Ricciardelli, T Bianco-Miotto, S Jindal, LM Butler… - Clinical Cancer …, 2018 - AACR
Purpose: Consensus is lacking regarding the androgen receptor (AR) as a prognostic
marker in breast cancer. The objectives of this study were to comprehensively review the …

[HTML][HTML] A genome-wide association scan on estrogen receptor-negative breast cancer

J Li, K Humphreys, H Darabi, G Rosin… - Breast Cancer …, 2010 - Springer
Introduction Breast cancer is a heterogeneous disease and may be characterized on the
basis of whether estrogen receptors (ER) are expressed in the tumour cells. ER status of …

The Prognosis and Predictive Value of Estrogen Negative/Progesterone Positive (ER−/PR+) Phenotype: Experience of 1159 Primary Breast Cancer from a Single …

S Gamrani, S Boukansa, Z Benbrahim… - The Breast …, 2022 - Wiley Online Library
Breast cancer is a serious worldwide public health problem and is currently the most
common cancer overall. Its endocrine therapy is related to the expression of the steroid …

[HTML][HTML] A nomogram for predicting the risk of male breast cancer for overall survival

Y Wen, J Bai, C Zheng, J Liu, S Lin, H Han… - Frontiers in …, 2023 - frontiersin.org
Background Male breast cancer (MBC) is a rare disease, accounting for< 1% of all male
carcinomas. Lack of prospective data, the current therapy for MBC is based on retrospective …

[HTML][HTML] Gene expression signature of estrogen receptor α status in breast cancer

MC Abba, Y Hu, H Sun, JA Drake, S Gaddis… - BMC genomics, 2005 - Springer
Background Estrogens are known to regulate the proliferation of breast cancer cells and to
modify their phenotypic properties. Identification of estrogen-regulated genes in human …

Joint relative risks for estrogen receptor-positive breast cancer from a clinical model, polygenic risk score, and sex hormones

Y Shieh, D Hu, L Ma, S Huntsman, CC Gard… - Breast cancer research …, 2017 - Springer
Background Models that predict the risk of estrogen receptor (ER)-positive breast cancers
may improve our ability to target chemoprevention. We investigated the contributions of sex …

[HTML][HTML] Deep learning-enabled breast cancer hormonal receptor status determination from base-level H&E stains

N Naik, A Madani, A Esteva, NS Keskar… - Nature …, 2020 - nature.com
For newly diagnosed breast cancer, estrogen receptor status (ERS) is a key molecular
marker used for prognosis and treatment decisions. During clinical management, ERS is …