Immune mechanisms and therapeutic potential of CpG oligodeoxynucleotides
Unmethylated CpG motifs in bacterial DNA and synthetic oligodeoxynucleotides activate
immune cells that express Toll-like Receptor 9. Activation through this receptor triggers …
immune cells that express Toll-like Receptor 9. Activation through this receptor triggers …
Impact of modifications of heterocyclic bases in CpG dinucleotides on their immune-modulatory activity
J Vollmer, RD Weeratna, M Jurk… - Journal of leukocyte …, 2004 - academic.oup.com
Synthetic phosphorothioate oligodeoxynucleotides (ODN) bearing unmethylated CpG motifs
can mimic the immune-stimulatory effects of bacterial DNA and are recognized by Toll-like …
can mimic the immune-stimulatory effects of bacterial DNA and are recognized by Toll-like …
Immunotherapeutic utility of stimulatory and suppressive oligodeoxynucleotides.
Bacterial DNA contains immunostimulatory CpG motifs that interact with toll-like receptor 9
on immune cells to stimulate the production of cytokines, chemokines and immunoglobulins …
on immune cells to stimulate the production of cytokines, chemokines and immunoglobulins …
Adjuvant properties of CpG oligonucleotides in primates
D Verthelyi - DNA Vaccines: Methods and Protocols, 2006 - Springer
Unlike mammalian DNA, bacterial, plasmid, and synthetic DNA containing unmethylated
CpG dinucleotides in specific sequence contexts are recognized by the Toll-like receptor 9 …
CpG dinucleotides in specific sequence contexts are recognized by the Toll-like receptor 9 …
Enhancing immunogenicity by CpG DNA.
W Jiang, DS Pisetsky - Current Opinion in Molecular Therapeutics, 2003 - europepmc.org
Bacterial DNA and oligonucleotides containing unmethylated CpG dinucleotides (CpG DNA)
can stimulate immune responses and have potential for use as novel agents to enhance …
can stimulate immune responses and have potential for use as novel agents to enhance …
Use of CpG oligodeoxynucleotides as immunoprotective agents
DM Klinman - Expert opinion on biological therapy, 2004 - Taylor & Francis
Single-stranded oligodeoxynucleotides (ODNs) synthesised to express unmethylated 'CpG
motifs' mimic the ability of bacterial DNA to trigger the innate immune system. CpG ODNs …
motifs' mimic the ability of bacterial DNA to trigger the innate immune system. CpG ODNs …
Toll-like receptor 9, CpG DNA and innate immunity
AA Ashkar, KL Rosenthal - Current molecular medicine, 2002 - ingentaconnect.com
Innate immunity provides the first line of defense against invading pathogens and is
essential for survival in the absence of adaptive immune responses. Innate immune …
essential for survival in the absence of adaptive immune responses. Innate immune …
[HTML][HTML] Cooperation of oligodeoxynucleotides and synthetic molecules as enhanced immune modulators
S Nigar, T Shimosato - Frontiers in Nutrition, 2019 - frontiersin.org
Unmethylated cytosine–guanine dinucleotide (CpG) motifs are potent stimulators of the host
immune response. Cellular recognition of CpG motifs occurs via Toll-like receptor 9 (TLR9) …
immune response. Cellular recognition of CpG motifs occurs via Toll-like receptor 9 (TLR9) …
Recent progress concerning CpG DNA and its use as a vaccine adjuvant
H Shirota, DM Klinman - Expert review of vaccines, 2014 - Taylor & Francis
CpG Oligonucleotides (ODN) are immunomodulatory synthetic oligonucleotides designed to
specifically agonize Toll-like receptor 9. Here, we review recent progress in understanding …
specifically agonize Toll-like receptor 9. Here, we review recent progress in understanding …
CpG oligonucleotides as vaccine adjuvants
N Kayraklioglu, B Horuluoglu, DM Klinman - DNA Vaccines: Methods and …, 2021 - Springer
CpG Oligonucleotides (ODN) are immunomodulatory synthetic oligonucleotides specifically
designed to stimulate Toll-like receptor 9. TLR9 is expressed on human plasmacytoid …
designed to stimulate Toll-like receptor 9. TLR9 is expressed on human plasmacytoid …