Essential fatty acids linoleic acid and α‐linolenic acid sex‐dependently regulate glucose homeostasis in obesity

P Zhuang, Q Shou, W Wang, L He… - Molecular nutrition & …, 2018 - Wiley Online Library
Scope To assess the associations of dietary linoleic acid (LA) and α‐linolenic acid (ALA)
with type 2 diabetes (T2D) risk in a population‐based cohort and further explore the …

Correlations between α-linolenic acid-improved multitissue homeostasis and gut microbiota in mice fed a high-fat diet

X Gao, S Chang, S Liu, L Peng, J Xie, W Dong, Y Tian… - Msystems, 2020 - Am Soc Microbiol
Previous studies have shown that α-linolenic acid (ALA) has a significant regulatory effect on
related disorders induced by high-fat diets (HFDs), but little is known regarding the …

Dietary intake of linoleic acid, its concentrations, and the risk of type 2 diabetes: a systematic review and dose-response meta-analysis of prospective cohort studies

SM Mousavi, Y Jalilpiran, E Karimi, D Aune… - Diabetes …, 2021 - Am Diabetes Assoc
BACKGROUND Earlier evidence on the association between dietary polyunsaturated fatty
acids and risk of diabetes has been conflicting. PURPOSE To quantitatively summarize …

Causal relationship between linoleic acid and type 2 diabetes and glycemic traits: a bidirectional Mendelian randomization study

H Liang, HB Mu, FH Zhang, WQ Li, GC Li… - Frontiers in …, 2023 - frontiersin.org
Objective To investigate the causal relationships between linoleic acid and type 2 diabetes,
and between linoleic acid and glycemic traits in European populations. Methods This study …

Eicosapentaenoic and docosahexaenoic acids differentially alter gut microbiome and reverse high‐fat diet–induced insulin resistance

P Zhuang, Y Zhang, Q Shou, H Li, Y Zhu… - Molecular Nutrition & …, 2020 - Wiley Online Library
Scope To assess the individual effects of dietary eicosapentaenoic acid (EPA) and
docosahexaenoic acid (DHA) on insulin resistance (IR), gut microbiome, and gut …

Linoleic acid, glycemic control and Type 2 diabetes

MA Belury, RM Cole, DB Snoke, T Banh… - … and Essential Fatty Acids, 2018 - Elsevier
Dietary fat quality, especially the intake of specific types of fatty acids, impacts the risk of
many chronic diseases, including cardiovascular diseases, certain cancers and type 2 …

Circulating linoleic acid and alpha-linolenic acid and glucose metabolism: the Hoorn Study

M Cabout, M Alssema, G Nijpels… - European journal of …, 2017 - Springer
Purpose Data on the relation between linoleic acid (LA) and alpha-linolenic acid (ALA) and
type 2 diabetes mellitus (T2DM) risk are scarce and inconsistent. The aim of this study was …

[HTML][HTML] Obese mice losing weight due to trans-10, cis-12 conjugated linoleic acid supplementation or food restriction harbor distinct gut microbiota

LJ den Hartigh, Z Gao, L Goodspeed, S Wang… - The Journal of …, 2018 - Elsevier
Abstract Background trans-10, cis-12 Conjugated linoleic acid (t10, c12-CLA) is a dietary
supplement that promotes weight loss by increasing fat oxidation and energy expenditure …

Linoleic acid and the regulation of glucose homeostasis: A review of the evidence

JS Hamilton, EL Klett - Prostaglandins, Leukotrienes and Essential Fatty …, 2021 - Elsevier
The consumption of linoleic acid (LA, ω-6 18: 2), the most common ω-6 polyunsaturated fatty
acid (PUFA) in the Modern Western diet (MWD), has significantly increased over the last …

Omega-3-supplemented fat diet drives immune metabolic response in visceral adipose tissue by modulating gut microbiota in a mouse model of obesity

ND Portela, C Galván, LM Sanmarco, G Bergero… - Nutrients, 2023 - mdpi.com
Obesity is a chronic, relapsing, and multifactorial disease characterized by excessive
accumulation of adipose tissue (AT), and is associated with inflammation mainly in white …