Omicron infection following vaccination enhances a broad spectrum of immune responses dependent on infection history

H Hornsby, AR Nicols, S Longet, C Liu, A Tomic… - Nature …, 2023 - nature.com
Pronounced immune escape by the SARS-CoV-2 Omicron variant has resulted in many
individuals possessing hybrid immunity, generated through a combination of vaccination …

Different neutralization profiles after primary SARS-CoV-2 Omicron BA. 1 and BA. 2 infections

I Medits, DN Springer, M Graninger, JV Camp… - Frontiers in …, 2022 - frontiersin.org
Background and Methods The SARS-CoV-2 (severe acute respiratory syndrome
coronavirus 2) Omicron (B. 1.1. 529) variant is the antigenically most distinct variant to date …

Antibody affinity and cross-variant neutralization of SARS-CoV-2 Omicron BA. 1, BA. 2 and BA. 3 following third mRNA vaccination

L Bellusci, G Grubbs, FT Zahra, D Forgacs… - Nature …, 2022 - nature.com
There is limited knowledge on durability of neutralization capacity and antibody affinity
maturation generated following two versus three doses of SARS-CoV-2 mRNA vaccines in …

[HTML][HTML] Vaccines elicit highly cross-reactive cellular immunity to the SARS-CoV-2 omicron variant

J Liu, A Chandrashekar, D Sellers, J Barrett, M Lifton… - MedRxiv, 2022 - ncbi.nlm.nih.gov
The highly mutated SARS-CoV-2 Omicron (B. 1.1. 529) variant has been shown to evade a
substantial fraction of neutralizing antibody responses elicited by current vaccines that …

SARS-CoV-2 Omicron triggers cross-reactive neutralization and Fc effector functions in previously vaccinated, but not unvaccinated, individuals

SI Richardson, VS Madzorera, H Spencer… - Cell Host & Microbe, 2022 - cell.com
Summary The SARS-CoV-2 Omicron variant escapes neutralizing antibodies elicited by
vaccines or infection. However, whether Omicron triggers cross-reactive humoral responses …

Correlates of protection and viral load trajectories in omicron breakthrough infections in triple vaccinated healthcare workers

U Marking, S Havervall, NG Norin, O Bladh… - Nature …, 2023 - nature.com
Vaccination offers protection against severe COVID-19 caused by SARS-CoV-2 omicron but
is less effective against infection. Characteristics such as serum antibody titer correlation to …

Previous immunity shapes immune responses to SARS-CoV-2 booster vaccination and Omicron breakthrough infection risk

L Pérez-Alós, CB Hansen… - Nature …, 2023 - nature.com
The heterogeneity of the SARS-CoV-2 immune responses has become considerably more
complex over time and diverse immune imprinting is observed in vaccinated individuals …

mRNA booster immunization elicits potent neutralizing serum activity against the SARS-CoV-2 Omicron variant

H Gruell, K Vanshylla, P Tober-Lau, D Hillus… - Nature medicine, 2022 - nature.com
The Omicron variant of SARS-CoV-2 is causing a rapid increase in infections across the
globe. This new variant of concern carries an unusually high number of mutations in key …

Antibody responses to Omicron BA. 4/BA. 5 bivalent mRNA vaccine booster shot

Q Wang, A Bowen, R Valdez, C Gherasim, A Gordon… - Biorxiv, 2022 - biorxiv.org
Abstract The SARS-CoV-2 Omicron variant and its numerous sub-lineages have exhibited a
striking ability to evade humoral immune responses induced by prior vaccination or …

mRNA-1273 or mRNA-Omicron boost in vaccinated macaques elicits comparable B cell expansion, neutralizing antibodies and protection against Omicron

M Gagne, JI Moliva, KE Foulds, SF Andrew, BJ Flynn… - BioRxiv, 2022 - biorxiv.org
SARS-CoV-2 Omicron is highly transmissible and has substantial resistance to antibody
neutralization following immunization with ancestral spike-matched vaccines. It is unclear …