Since the first gap junction protein (connexin) was cloned over a decade ago, more than a
dozen connexin genes have been cloned. Consequently, a wealth of information on the …

These are challenging times for scientists characterizing signaling pathways of their special
interest, because the techniques employed to analyze molecular functions or interactions …

The most significant finding of the past year in gap junction research has been the
association of connexin defects with human diseases. Connexin32 mutations cause X …

Gap junctions are essential to the function of multicellular animals, which require a high
degree of coordination between cells. In vertebrates, gap junctions comprise connexins and …

The vertebrate gap junctions formed by the connexin family of transmembrane proteins
came to the attention of geneticists in 1993 with the identification of mutations linked to a …

Gap junctions are clusters of intercellular channels between adjacent cells. The channels
are formed by the direct apposition of oligomeric transmembrane proteins, permitting the …

Gap junctions (GJ) provide direct intercellular communication. The structures underlying
these cell junctions are membrane-associated channels composed of six integral membrane …

Gap junctions are plasma membrane spatial microdomains constructed of assemblies of
channel proteins called connexins in vertebrates and innexins in invertebrates. The …

Connexin proteins make intercellular channels–gap junctions–which provide a direct
pathway for cell–cell signaling in vertebrates. Studies of mice lacking connexin genes have …

Sáez, Juan C., Viviana M. Berthoud, María C. Brañes, Agustín D. Martínez, and Eric C.
Beyer. Plasma Membrane Channels Formed by Connexins: Their Regulation and Functions …