Abstract Charcot–Marie–Tooth disease (CMT) is the most common inherited peripheral
neuropathy, with an estimated prevalence of 1 in 2500. The degeneration of motor and …

Background and Purpose Charcot–Marie–Tooth (CMT) disease is the most common
hereditary peripheral neuropathy. CMT type 1A (CMT1A) accounts for approximately 50% of …

Abstract Histone deacetylase 6 (HDAC6) plays a central role in various processes that are
key for neuronal survival. In this review, we summarize the current evidence related to …

Abstract Charcot–Marie–Tooth disease (CMT) is the most common inherited peripheral
neuropathy, with currently no effective treatment or cure. CMT1A is caused by a duplication …

Abstract Charcot‐Marie‐Tooth disease type 2D (CMT2D), is a hereditary peripheral
neuropathy caused by mutations in the gene encoding glycyl‐tRNA synthetase (GARS1) …

Disruption of axonal transport causes a number of rare, inherited axonopathies and is
heavily implicated in a wide range of more common neurodegenerative disorders, many of …

Charcot–Marie–Tooth (CMT) disease is a disorder of the peripheral nervous system where
progressive degeneration of motor and sensory nerves leads to motor problems and …

There is still no effective drug treatment available for Charcot-Marie-Tooth neuropathies
(CMT). Current management relies on rehabilitation therapy, surgery for skeletal deformities …

Charcot-Marie-Tooth disease is the most common inherited disorder of the peripheral
nervous system. The disease is characterized by a progressive muscle weakness and …

Histone deacetylase 6 (HDAC6) is a promising therapeutic target for the treatment of
neurodegenerative disorders. SW-100 (1a), a phenylhydroxamate-based HDAC6 inhibitor …