[HTML][HTML] Neuronal stress and injury caused by HIV-1, cART and drug abuse: converging contributions to HAND
AB Sanchez, M Kaul - Brain sciences, 2017 - mdpi.com
Multiple mechanisms appear to contribute to neuronal stress and injury underlying HIV-
associated neurocognitive disorders (HAND), which occur despite the successful …
associated neurocognitive disorders (HAND), which occur despite the successful …
[HTML][HTML] Beneficial and adverse effects of cART affect neurocognitive function in HIV-1 infection: balancing viral suppression against neuronal stress and injury
HIV-associated neurocognitive disorders (HAND) persist despite the successful introduction
of combination antiretroviral therapy (cART). While insufficient concentration of certain …
of combination antiretroviral therapy (cART). While insufficient concentration of certain …
Antiretrovirals, methamphetamine, and HIV-1 envelope protein gp120 compromise neuronal energy homeostasis in association with various degrees of synaptic and …
AB Sanchez, GP Varano, CM de Rozieres… - Antimicrobial agents …, 2016 - Am Soc Microbiol
ABSTRACT HIV-1 infection frequently causes HIV-associated neurocognitive disorders
(HAND) despite combination antiretroviral therapy (cART). Evidence is accumulating that …
(HAND) despite combination antiretroviral therapy (cART). Evidence is accumulating that …
[HTML][HTML] Antiretroviral drugs induce oxidative stress and neuronal damage in the central nervous system
HIV-associated neurocognitive disorder (HAND), characterized by a wide spectrum of
behavioral, cognitive, and motor dysfunctions, continues to affect approximately 50% of HIV …
behavioral, cognitive, and motor dysfunctions, continues to affect approximately 50% of HIV …
[HTML][HTML] Pathogenesis of HIV in the central nervous system
V Valcour, P Sithinamsuwan, S Letendre… - Current Hiv/aids …, 2011 - Springer
HIV can infect the brain and impair central nervous system (CNS) function. Combination
antiretroviral therapy (cART) has not eradicated CNS complications. HIV-associated …
antiretroviral therapy (cART) has not eradicated CNS complications. HIV-associated …
[HTML][HTML] N-Acetylcysteine reverses antiretroviral-mediated microglial activation by attenuating autophagy-lysosomal dysfunction
Successful suppression of viral replication by combined antiretroviral therapy (cART) in HIV-
1 infected individuals is paradoxically also accompanied by an increased prevalence of HIV …
1 infected individuals is paradoxically also accompanied by an increased prevalence of HIV …
[HTML][HTML] Neuropathology of HAND with suppressive antiretroviral therapy: encephalitis and neurodegeneration reconsidered
BB Gelman - Current Hiv/Aids Reports, 2015 - Springer
HIV-1 infiltrates the central nervous system (CNS) during the initial infection and thereafter
plays a persistent role in producing CNS dysfunction as the disease progresses. HIV …
plays a persistent role in producing CNS dysfunction as the disease progresses. HIV …
The impact of substance abuse on HIV-mediated neuropathogenesis in the current ART era
V Chilunda, TM Calderon, P Martinez-Aguado… - Brain research, 2019 - Elsevier
Approximately 37 million people worldwide are infected with human immunodeficiency virus
(HIV). One highly significant complication of HIV infection is the development of HIV …
(HIV). One highly significant complication of HIV infection is the development of HIV …
HIV-associated neurocognitive disorder—pathogenesis and prospects for treatment
In the past two decades, several advancements have improved the care of HIV-infected
individuals. Most importantly, the development and deployment of combination antiretroviral …
individuals. Most importantly, the development and deployment of combination antiretroviral …
[HTML][HTML] Potential pharmacological approaches for the treatment of HIV-1 associated neurocognitive disorders
A Omeragic, O Kayode, MT Hoque… - Fluids and Barriers of the …, 2020 - Springer
HIV associated neurocognitive disorders (HAND) are the spectrum of cognitive impairments
present in patients infected with human immunodeficiency virus type 1 (HIV-1). The number …
present in patients infected with human immunodeficiency virus type 1 (HIV-1). The number …