Versatility of cell-penetrating peptides for intracellular delivery of siRNA
The plasma membrane is a large barrier to systemic drug delivery into cells, and it limits the
efficacy of drug cargo. This issue has been overcome using cell-penetrating peptides …
efficacy of drug cargo. This issue has been overcome using cell-penetrating peptides …
Cell-penetrating peptides (CPPs) as a vector for the delivery of siRNAs into cells
I Nakase, G Tanaka, S Futaki - Molecular BioSystems, 2013 - pubs.rsc.org
“Cell-penetrating peptides (CPPs)” is an inclusive term describing relatively small peptides
(6− 30 amino acid residues) having membrane translocation activity. Due to their efficacy in …
(6− 30 amino acid residues) having membrane translocation activity. Due to their efficacy in …
Exogenous siRNA delivery using peptide transduction domains/cell penetrating peptides
BR Meade, SF Dowdy - Advanced drug delivery reviews, 2007 - Elsevier
The cellular membrane constitutes an effective barrier that offers protection for the complex,
yet highly ordered, intracellular environment that defines the cell. Passage of molecules …
yet highly ordered, intracellular environment that defines the cell. Passage of molecules …
A non-covalent peptide-based strategy for siRNA delivery
L Crombez, G Divita - Cell-penetrating peptides: methods and protocols, 2011 - Springer
The development of short-interfering RNA (siRNA) has provided great hope for therapeutic
targeting of specific genes responsible for pathological disorders. However, the poor cellular …
targeting of specific genes responsible for pathological disorders. However, the poor cellular …
Comparison of cationic and amphipathic cell penetrating peptides for siRNA delivery and efficacy
Cell penetrating peptides (CPPs) are short strands of arginine-and/or lysine-rich peptides (<
30 amino acids) that use their cationic nature for efficient intracellular accumulation. CPPs …
30 amino acids) that use their cationic nature for efficient intracellular accumulation. CPPs …
Cationic cell-penetrating peptides as vehicles for siRNA delivery
RNA interference mediated gene silencing has tremendous applicability in fields ranging
from basic biological research to clinical therapy. However, delivery of siRNA across the cell …
from basic biological research to clinical therapy. However, delivery of siRNA across the cell …
Cell-penetrating peptides delivering siRNAs: an overview
Abstract Cell-Penetrating Peptides (CPP) are valuable tools capable of crossing the plasma
membrane to deliver therapeutic cargo inside cells. Small interfering RNAs (siRNA) are …
membrane to deliver therapeutic cargo inside cells. Small interfering RNAs (siRNA) are …
Recent in vivo advances in cell-penetrating peptide-assisted drug delivery
Introduction: Delivery of macromolecular drugs is an important field in medical research.
However, macromolecules are usually unable to cross the cell membrane without the …
However, macromolecules are usually unable to cross the cell membrane without the …
A new potent secondary amphipathic cell–penetrating peptide for siRNA delivery into mammalian cells
L Crombez, G Aldrian-Herrada, K Konate, QN Nguyen… - Molecular therapy, 2009 - cell.com
RNA interference constitutes a powerful tool for biological studies, but has also become one
of the most challenging therapeutic strategies. However, small interfering RNA (siRNA) …
of the most challenging therapeutic strategies. However, small interfering RNA (siRNA) …
Uptake mechanism and direct translocation of a new CPP for siRNA delivery
Since their development, cell-penetrating peptides (CPPs) have been used as delivery
vehicles for various genetic or therapeutic agents; however, the uptake mechanisms of …
vehicles for various genetic or therapeutic agents; however, the uptake mechanisms of …