Background Chronotherapeutic techniques (sleep deprivation and light therapy) are
effective treatments for bipolar depression, but viable predictors of response for the daily …

Patient diurnal mood fluctuation, sleep characteristics and factors affecting sleep
homeostasis predict antidepressant response to the combination of total sleep deprivation …

Background The combination of three cycles of sleep deprivation (SD), light therapy (LT),
and lithium has recently been proposed as a possible first-line treatment for bipolar …

Background The combination of sleep deprivation and light therapy, called combined
chronotherapy, may yield positive short-and long-term results, even in patients with …

Background Sleep disturbances are a fundamental feature of depression, with their
persistence after remission serving as a key risk factor for recurrence of depressive …

The combination of total sleep deprivation (TSD) and light therapy (LT) in bipolar depression
causes rapid antidepressant effects, and its mechanism of action has been hypothesized to …

Background The aim of the study was to examine the efficacy and safety of morning bright
light therapy (BLT) in the treatment of patients with a current major depressive episode …

Objective: Patients with bipolar disorder have recurrent major depression, residual mood
symptoms, and limited treatment options. Building on promising pilot data, the authors …

Purpose: To compare effects of bright light therapy (BLT) alone or combined with the
selective serotonin reuptake inhibitor (SSRI) fluoxetine, on severity of depression, circadian …

Background Triple chronotherapy (wake night [one night without sleep], sleep phase
advance, and early morning bright light exposure) demonstrated rapid efficacy primarily in …