Although melanin is a photoprotective pigment, its elevated photochemical reactivity could
lead to various phototoxic processes. Photoreactivity of synthetic pheomelanin, derived from …

In this work, we examined photoreactivity of synthetic eumelanins, formed by autooxidation
of DOPA, or enzymatic oxidation of 5, 6‐dihydroxyindole‐2‐carboxylic acid and synthetic …

Eumelanin is photoprotective for pigmented tissues while pheomelanin is phototoxic. In this
review, we summarize current understanding of how eumelanin and pheomelanin structures …

Eumelanin is photoprotective while pheomelanin is phototoxic to pigmented tissues.
Ultraviolet A (UVA)‐induced tanning seems to result from the photooxidation of pre‐existing …

When aging, melanin in human retinal pigment epithelium (RPE) undergoes oxidative
modifications, which increase its photoreactivity and reduce its antioxidant capacity …

Melanins are thought to be important modulators of photochemistry in skin. Eumelanin, a
black-brown pigment, is believed to protect against UV-induced photodamage, whereas …

Even though melanin is commonly viewed as natural photoprotectant, the pigment
demonstrates residual photoreactivity, which under certain conditions could contribute to …

The abnormal susceptibility of red‐haired individuals to UV‐induced inflammation and skin
cancers is commonly attributed to the marked photoreactivity of pheomelanin pigments …

A new in vitro model system for studying the photochemistry and photobiology of melanins in
epidermal tissue has been developed. The photochemistry of phaeomelanin in this model …

Pheomelanin, the sulfurated form of melanin pigment, is known to produce reactive oxygen
species (ROS) and oxidative stress-mediated cytotoxicity. Previous studies have shown a …