A new in vitro model system for studying the photochemistry and photobiology of melanins in
epidermal tissue has been developed. The photochemistry of phaeomelanin in this model …

Pheomelanin, the sulfurated form of melanin pigment, is known to produce reactive oxygen
species (ROS) and oxidative stress-mediated cytotoxicity. Previous studies have shown a …

Photoreactivity of melanin has become a major focus of research due to the postulated
involvement of the pigment in UVA-induced melanoma. However, most of the hitherto …

Pheomelanogenesis is a complex pathway that starts with the oxidation of tyrosine (or
DOPA, 3, 4‐dihydroxyphenylalanine) by tyrosinase in the presence of cysteine, which …

Melanin is known to be photoreactive and photoprotective, but its function in skin in vivo is
still debated. Data is lacking of the effects of UVA irradiation on human skin melanosomes of …

The human skin and eye melanin is commonly viewed as an efficient photoprotective agent.
To elucidate the molecular mechanism of the melanin-dependent photoprotection, we …

The characteristic absorption and photochemical properties of pheomelanins are generally
attributed to “benzothiazine” structural units derived biogenetically from 5‐S‐cysteinyldopa …

The photochemical behavior of 5‐S‐cysteinyldopa (5‐S‐CD), a colorless product of
melanocyte metabolism, was investigated in neutral phosphate buffer with biologically …

Eumelanin photoprotects pigmented tissues from ultraviolet (UV) damage. However, UVA‐
induced tanning seems to result from the photooxidation of preexisting melanin and does …

Cysteinyldopas, metabolic by‐products of activated melanocytes, are photochemically
unstable in the presence of biologically relevant ultraviolet radiation (ie wavelengths> 300 …