Population Genomics of Chlamydia trachomatis: Insights on Drift, Selection, Recombination, and Population Structure

SJ Joseph, X Didelot, J Rothschild… - Molecular biology …, 2012 - academic.oup.com
The large number of sexually transmitted diseases and ocular trachoma cases that are
caused globally each year by Chlamydia trachomatis has made this organism a World …

Whole-genome analysis of diverse Chlamydia trachomatis strains identifies phylogenetic relationships masked by current clinical typing

SR Harris, IN Clarke, HMB Seth-Smith, AW Solomon… - Nature …, 2012 - nature.com
Chlamydia trachomatis is responsible for both trachoma and sexually transmitted infections,
causing substantial morbidity and economic cost globally. Despite this, our knowledge of its …

Interplay of recombination and selection in the genomes of Chlamydia trachomatis

SJ Joseph, X Didelot, K Gandhi, D Dean, TD Read - Biology direct, 2011 - Springer
Background Chlamydia trachomatis is an obligate intracellular bacterial parasite, which
causes several severe and debilitating diseases in humans. This study uses comparative …

Genomic features beyond Chlamydia trachomatis phenotypes: what do we think we know?

A Nunes, MJ Borrego, JP Gomes - Infection, Genetics and Evolution, 2013 - Elsevier
The obligate intracellular pathogen Chlamydia trachomatis is the causative agent of the
blinding trachoma and the world's leading cause of bacterial sexually transmitted infections …

Chlamydia trachomatisdiversity viewed as a tissue-specific coevolutionary arms race

A Nunes, PJ Nogueira, MJ Borrego, JP Gomes - Genome biology, 2008 - Springer
Background The genomes of pathogens are thought to have evolved under selective
pressure provided by the host in a coevolutionary arms race (the'Red Queen's Hypothesis') …

Evolution of Chlamydia trachomatis diversity occurs by widespread interstrain recombination involving hotspots

JP Gomes, WJ Bruno, A Nunes, N Santos… - Genome …, 2007 - genome.cshlp.org
Chlamydia trachomatis is an obligate intracellular bacterium of major public health
significance, infecting over one-tenth of the world's population and causing blindness and …

Evolution, phylogeny, and molecular epidemiology of Chlamydia

A Nunes, JP Gomes - Infection, Genetics and Evolution, 2014 - Elsevier
The Chlamydiaceae are a family of obligate intracellular bacteria characterized by a unique
biphasic developmental cycle. It encompasses the single genus Chlamydia, which involves …

Effect of long-term laboratory propagation on Chlamydia trachomatis genome dynamics

V Borges, R Ferreira, A Nunes, M Sousa-Uva… - Infection, Genetics and …, 2013 - Elsevier
It is assumed that bacterial strains maintained in the laboratory for long time shape their
genome in a different fashion from the nature-circulating strains. Here, we analyzed the …

[HTML][HTML] Predicting phenotype and emerging strains among Chlamydia trachomatis infections

D Dean, WJ Bruno, R Wan, JP Gomes… - Emerging infectious …, 2009 - ncbi.nlm.nih.gov
Chlamydia trachomatis is a global cause of blinding trachoma and sexually transmitted
infections (STIs). We used comparative genomics of the family Chlamydiaceae to select …

Genomic and phenotypic characterization of in vitro-generated Chlamydia trachomatis recombinants

BM Jeffrey, RJ Suchland, SG Eriksen, KM Sandoz… - BMC microbiology, 2013 - Springer
Background Pre-genomic and post-genomic studies demonstrate that chlamydiae actively
recombine in vitro and in vivo, although the molecular and cellular biology of this process is …