Five major psychiatric disorders and Alzheimer's disease: a Bidirectional Mendelian Randomization Study

T Wei, Z Guo, Z Wang, C Li, W Zhu… - Journal of …, 2022 - content.iospress.com
Background: Extensive studies put forward the association between Alzheimer's disease
(AD) and psychiatric disorders; however, it remains unclear whether these associations are …

Systematic evaluation of multifactorial causal associations for Alzheimer's disease and an interactive platform based on Mendelian randomization analysis——MRAD

T Zhao, H Li, M Zhang, Y Xu, M Zhang, L Chen - medRxiv, 2024 - medrxiv.org
Alzheimer's disease (AD) is a complex degenerative disease of the central nervous system.
Traditional epidemiological studies have reported several risk factors for AD. However, most …

Causal influences of neuropsychiatric disorders on Alzheimer's disease

A Baranova, Q Zhao, H Cao, V Chandhoke… - Translational …, 2024 - nature.com
Previous studies have observed a significant comorbidity between Alzheimer's disease (AD)
and some other neuropsychiatric disorders. However, the mechanistic connections between …

Mendelian Randomization Analysis Reveals Causal Factors behind Alzheimer's Disease Risk: Evidence, Opportunities, and Challenges

X Feng, L Zhang, Y Hou, W Ma, J Ma, X Chang… - The Journal of …, 2024 - Springer
Alzheimer's disease and its comorbidities pose a heavy disease burden globally, and its
treatment remains a major challenge. Identifying the protective and risk factors for …

[HTML][HTML] Detecting potential causal relationship between multiple risk factors and Alzheimer's disease using multivariable Mendelian randomization

Q Zhang, F Xu, L Wang, WD Zhang, CQ Sun… - Aging (Albany …, 2020 - ncbi.nlm.nih.gov
Background: Alzheimer's disease (AD) is a progressive brain disorder characterized by
cognitive skills deterioration that affects many elderly individuals. The identified genetic loci …

Multigenomics reveals the causal effect of herpes simplex virus in Alzheimer's disease: a two-sample Mendelian randomization study

Y Zhang, J Qu, LI Luo, Z Xu, X Zou - Frontiers in Genetics, 2022 - frontiersin.org
In recent years, the herpes virus infectious hypothesis for Alzheimer's disease (AD) has
gained support from an increasing number of researchers. Herpes simplex virus (HSV) is a …

Rheumatoid arthritis is a protective factor against Alzheimer's disease: a bidirectional two-sample Mendelian randomization study

GS Li, YZ Yang, GR Ma, PF Li, QH Cheng… - …, 2024 - Springer
Background Epidemiological evidence suggests that there is an association between
rheumatoid arthritis (RA) and Alzheimer's disease (AD). However, the causal relationship …

Stroke and Alzheimer's disease: A mendelian randomization study

T Wang, Q Ni, K Wang, Z Han, B Sun - Frontiers in Genetics, 2020 - frontiersin.org
Stroke and Alzheimer's disease (AD) are common neurological diseases. Several exiting
studies indicated that late onset-AD and ischemic stroke have shared genetic links. Different …

Causal relationships between type 1 diabetes mellitus and Alzheimer's disease and Parkinson's disease: a bidirectional two-sample Mendelian randomization study

C Geng, K Meng, B Zhao, X Liu, Y Tang - European Journal of Medical …, 2024 - Springer
Background Previous compelling evidence suggests an association between Type 2
diabetes (T2D) and neurodegenerative diseases. However, it remains uncertain whether …

[HTML][HTML] Bidirectional Mendelian randomization study of psychiatric disorders and Parkinson's disease

Q Wu, S Liu, X Huang, J Liu, Y Wang… - Frontiers in Aging …, 2023 - frontiersin.org
Although the relationship between psychiatric disorders and Parkinson's disease (PD) has
attracted continuous research attention, the causal linkage between them has not reached a …