Immunological Pathways Triggered by Porphyromonas gingivalis and Fusobacterium nucleatum: Therapeutic Possibilities?

KQ De Andrade, CLC Almeida-da-Silva… - Mediators of …, 2019 - Wiley Online Library
Porphyromonas gingivalis (P. gingivalis) and Fusobacterium nucleatum (F. nucleatum) are
Gram‐negative anaerobic bacteria possessing several virulence factors that make them …

Modulation of inflammasome activity by Porphyromonas gingivalis in periodontitis and associated systemic diseases

I Olsen, Ö Yilmaz - Journal of oral microbiology, 2016 - Taylor & Francis
Inflammasomes are large multiprotein complexes localized in the cytoplasm of the cell. They
are responsible for the maturation of pro-inflammatory cytokines such as interleukin-1β (IL …

Porphyromonas gingivalis triggers NLRP3‐mediated inflammasome activation in macrophages in a bacterial gingipains‐independent manner

T Okano, H Ashida, S Suzuki, M Shoji… - European journal of …, 2018 - Wiley Online Library
Porphyromonas gingivalis is a Gram‐negative anaerobic bacterium that has been
considered to be one of the bacteria associated with progression of human periodontitis …

Porphyromonas gingivalis-Induced NLRP3 Inflammasome Activation and Its Downstream Interleukin-1β Release Depend on Caspase-4

PH Ding, MX Yang, NN Wang, LJ Jin, Y Dong… - Frontiers in …, 2020 - frontiersin.org
Background: Oral commensals contribute to microbe-host symbiosis in periodontal
homeostasis, and Porphyromonas gingivalis (P. gingivalis) as the keystone pathogen …

Regulation of the NLRP3 inflammasome in Porphyromonas gingivalis-accelerated periodontal disease

Y Yamaguchi, T Kurita-Ochiai, R Kobayashi… - Inflammation …, 2017 - Springer
Objective Porphyromonas gingivalis is involved in the pathogenesis of chronic inflammatory
periodontal disease. Recent studies have suggested that the NLRP3 inflammasome plays …

Identification of signaling pathways in macrophage exposed to Porphyromonas gingivalis or to its purified cell wall components

Q Zhou, S Amar - The Journal of Immunology, 2007 - journals.aai.org
Porphyromonas gingivalis (P. gingivalis) can trigger an inflammatory condition leading to the
destruction of periodontal tissues. However P. gingivalis LPS and its fimbriae (FimA) play …

Fusobacterium nucleatum infection of gingival epithelial cells leads to NLRP3 inflammasome‐dependent secretion of IL‐1β and the danger signals ASC and HMGB1

FQ Bui, L Johnson, JA Roberts, SC Hung… - Cellular …, 2016 - Wiley Online Library
Fusobacterium nucleatum is an invasive anaerobic bacterium that is associated with
periodontal disease. Previous studies have focused on virulence factors produced by F …

RETRACTED ARTICLE: Temporal activation of anti-and pro-apoptotic factors in human gingival fibroblasts infected with the periodontal pathogen, Porphyromonas …

S Urnowey, T Ansai, V Bitko, K Nakayama… - BMC microbiology, 2006 - Springer
Background Porphyromonas gingivalis is the foremost oral pathogen of adult periodontitis in
humans. However, the mechanisms of bacterial invasion and the resultant destruction of the …

Activation of NLRP3 and AIM2 inflammasomes by Porphyromonas gingivalis infection

E Park, HS Na, YR Song, SY Shin, YM Kim… - Infection and …, 2014 - Am Soc Microbiol
Porphyromonas gingivalis, a major periodontopathogen, is involved in the pathogenesis of
periodontitis. Interleukin-1β (IL-1β), a proinflammatory cytokine, regulates innate immune …

Periodontopathogens Porphyromonas gingivalis and Fusobacterium nucleatum and Their Roles in the Progression of Respiratory Diseases

T Shi, J Wang, J Dong, P Hu, Q Guo - Pathogens, 2023 - mdpi.com
The intricate interplay between oral microbiota and the human host extends beyond the
confines of the oral cavity, profoundly impacting the general health status. Both periodontal …