Hippocampal CA1 pyramidal neurons, a major component of the medial temporal lobe
memory circuit, are selectively vulnerable during the progression of Alzheimer's disease …

Background Nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF),
neurotrophin 3 (NT-3), and neurotrophin 4/5 (NT-4/5) are members of the neurotrophin gene …

BACKGROUND: Endocytic dysfunction and neurotrophin signaling deficits may underlie the
selective vulnerability of hippocampal neurons during the progression of Alzheimer's …

Down syndrome (DS) is the most prevalent cause of intellectual disability (ID). Individuals
with DS show a variety of cognitive deficits, most notably in hippocampal learning and …

Introduction Downregulation of brain-derived neurotrophic factor (BDNF) and its cognate
neurotrophin receptor, TrkB, were observed during the progression of dementia, but whether …

Down syndrome (DS) is caused by the triplication of human chromosome 21 (HSA21) and is
the most common genetic cause of intellectual disability, with individuals having deficits in …

Clinical neuropathologic studies suggest that the selective vulnerability of hippocampal CA1
pyramidal projection neurons plays a key role in the onset of cognitive impairment during the …

To evaluate molecular signatures of an individual cell type in comparison to the associated
region relevant towards understanding the pathogenesis of Alzheimer's disease (AD), CA1 …

This article reviews the current progress in our understanding of the mechanisms by which
growth factors, including brain-derived neurotrophic factor (BDNF) and vascular endothelial …

A major problem in the field of neurodegeneration is the basis of selective vulnerability of
subsets of neurons to disease. In aging, Alzheimer's disease (AD), and other disorders such …