Background Population-based estimates of the risk of breast cancer associated with
germline pathogenic variants in cancer-predisposition genes are critically needed for risk …

Importance Germline pathogenic variants inBRCA1andBRCA2predispose to an increased
lifetime risk of breast cancer. However, the relevance of germline variants in other genes …

Understanding the gene-specific risks for development of breast cancer will lead to
improved clinical care for those carrying germline mutations in cancer predisposition genes …

Purpose Genome-wide association studies have identified common genomic variants
associated with increased susceptibility to breast cancer. In the general population, the risk …

Genetic and lifestyle/environmental factors are implicated in the aetiology of breast cancer.
This review summarizes the current state of knowledge on rare high penetrance mutations …

More than 12% of women will be diagnosed with breast cancer in their lifetime. Although
there have been tremendous advances in elucidating genetic risk factors underlying both …

Germline mutations in BRCA1 and BRCA2 confer high risks of female breast and ovarian
cancer. However, there is strong evidence that these risks are modified by other factors …

In recent years, our understanding of genetic predisposition to breast cancer has advanced
significantly. Three classes of predisposition factors, categorized by their associated risks of …

PURPOSE This study assessed the joint association of pathogenic variants (PVs) in breast
cancer (BC) predisposition genes and polygenic risk scores (PRS) with BC in the general …

Germline mutations in BRCA1 and BRCA2 confer high risks of breast cancer. However,
evidence suggests that these risks are modified by other genetic or environmental factors …