Nonopioid GTS-21 mitigates burn injury pain in rats by decreasing spinal cord inflammatory responses
Y Zhou, Y Leung-Pitt, H Deng, Y Ren, Z You… - Anesthesia & …, 2021 - journals.lww.com
Background: Burn injury (BI) pain consists of inflammatory and neuropathic components and
activates microglia. Nicotinic alpha 7 acetylcholine receptors (α7AChRs) expressed in …
activates microglia. Nicotinic alpha 7 acetylcholine receptors (α7AChRs) expressed in …
[HTML][HTML] The nonopioid cholinergic agonist GTS-21 mitigates morphine-induced aggravation of burn injury pain together with inhibition of spinal microglia activation in …
Y Ren, Y Zhou, Z You, H Deng, WR Kem, J Mao… - British Journal of …, 2022 - Elsevier
Background Repetitive opioid use does not always alleviate basal pain, procedural pain, or
both after burn injury. Mitigation of burn injury-site pain can be achieved by GTS-21 …
both after burn injury. Mitigation of burn injury-site pain can be achieved by GTS-21 …
Intrathecal injection of an alpha seven nicotinic acetylcholine receptor agonist attenuates gp120-induced mechanical allodynia and spinal pro-inflammatory cytokine …
LC Loram, JA Harrison, L Chao, FR Taylor… - Brain, behavior, and …, 2010 - Elsevier
Nicotinic acetylcholine receptors (nAchRs) are not only key receptors in the autonomic
nervous system, but also are present on immune cells. The alpha seven subunit of nAchR …
nervous system, but also are present on immune cells. The alpha seven subunit of nAchR …
[HTML][HTML] Systemic administration of an alpha-7 nicotinic acetylcholine agonist reverses neuropathic pain in male Sprague Dawley rats
LC Loram, FR Taylor, KA Strand, SF Maier… - The Journal of …, 2012 - Elsevier
Alpha-7 nicotinic acetylcholine receptor (α7 nAChR) agonists attenuate pain and
inflammation in preclinical models. This study tested whether systemic delivery of an α7 …
inflammation in preclinical models. This study tested whether systemic delivery of an α7 …
[HTML][HTML] Inhibition of peripheral macrophages by nicotinic acetylcholine receptor agonists suppresses spinal microglial activation and neuropathic pain in mice with …
N Kiguchi, D Kobayashi, F Saika, S Matsuzaki… - Journal of …, 2018 - Springer
Background Neuro–immune interaction underlies chronic neuroinflammation and aberrant
sensory processing resulting in neuropathic pain. Despite the pathological significance of …
sensory processing resulting in neuropathic pain. Despite the pathological significance of …
Spinal activation of alpha7-nicotinic acetylcholine receptor attenuates posttraumatic stress disorder-related chronic pain via suppression of glial activation
R Sun, W Zhang, J Bo, Z Zhang, Y Lei, W Huo, Y Liu… - Neuroscience, 2017 - Elsevier
The high prevalence of chronic pain in posttraumatic stress disorder (PTSD) individuals has
been widely reported by clinical studies, which emphasized an urgent need to uncover the …
been widely reported by clinical studies, which emphasized an urgent need to uncover the …
Perioperative activation of spinal α7 nAChR promotes recovery from preoperative stress-induced prolongation of postsurgical pain
R Sun, Y Liu, B Hou, Y Lei, J Bo, W Zhang… - Brain, Behavior, and …, 2019 - Elsevier
Preoperative stress could delay the recovery of postoperative pain and has been reported to
be a risk factor for chronic postsurgical pain. As stress could facilitate the proinflammatory …
be a risk factor for chronic postsurgical pain. As stress could facilitate the proinflammatory …
Curcumin analogue NL04 inhibits spinal cord central sensitization in rats with bone cancer pain by inhibiting NLRP3 inflammasome activation and reducing IL-1β …
L Chen, B Hua, Q He, Z Han, Y Wang, Y Chen… - European Journal of …, 2024 - Elsevier
The management and therapy of bone cancer pain (BCP) remain formidable clinical
challenges. Curcumin and its analogues have been shown to have anti-inflammatory and …
challenges. Curcumin and its analogues have been shown to have anti-inflammatory and …
The role of dorsal root ganglia alpha-7 nicotinic acetylcholine receptor in complete Freund's adjuvant-induced chronic inflammatory pain
X Zhang, F Xu, L Wang, J Li, J Zhang, L Huang - Inflammopharmacology, 2021 - Springer
Background Alpha-7 nicotinic acetylcholine receptor (α7 nAChR) was reported to have a
critical role in the regulation of pain sensitivity and neuroinflammation. However, the …
critical role in the regulation of pain sensitivity and neuroinflammation. However, the …
Astroglial MicroRNA-219-5p in the ventral tegmental area regulates nociception in rats
S Zhang, XN Yang, T Zang, J Luo, Z Pan, L Wang… - …, 2017 - pubs.asahq.org
Background The authors previously reported that noncoding microRNA miR-219-5p is down-
regulated in the spinal cord in a nociceptive state. The ventral tegmental area also plays …
regulated in the spinal cord in a nociceptive state. The ventral tegmental area also plays …