Apixaban and rivaroxaban use for atrial fibrillation in patients with obesity and BMI ≥50 kg/m2
CP O'Kane, JCO Avalon, JL Lacoste… - … : The Journal of …, 2022 - Wiley Online Library
Background Apixaban and rivaroxaban are increasingly used for thromboembolism
prophylaxis in patients with non‐valvular atrial fibrillation (NVAF) and commonly in patients …
prophylaxis in patients with non‐valvular atrial fibrillation (NVAF) and commonly in patients …
Real-world effectiveness and safety of rivaroxaban versus warfarin among non-valvular atrial fibrillation patients with obesity in a US population
JS Berger, F Laliberté, A Kharat, D Lejeune… - Current Medical …, 2021 - Taylor & Francis
Objectives Current evidence indicates that the pharmacokinetic profile of rivaroxaban is not
significantly impacted by body weight. However, real-world data are needed to better assess …
significantly impacted by body weight. However, real-world data are needed to better assess …
Body mass index influence on the clinical outcomes for nonvalvular atrial fibrillation patients admitted to a hospital treated with direct oral anticoagulants: a …
X Li, C Zuo, Q Ji, Y Xue, Z Wang… - Drug design, development …, 2021 - Taylor & Francis
Background Considering that the current fixed dose of direct oral anticoagulants (DOACs)
might have insufficient anticoagulation effect for overweight patients, the aim of this study …
might have insufficient anticoagulation effect for overweight patients, the aim of this study …
Effectiveness and safety of rivaroxaban versus warfarin in obese nonvalvular atrial fibrillation patients: analysis of electronic health record data
OS Costa, J Beyer-Westendorf, V Ashton… - Current Medical …, 2020 - Taylor & Francis
Background: Although rivaroxaban has demonstrated consistent drug levels in normal
weight and obese patients, sufficient confirmation of equal clinical effectiveness and safety is …
weight and obese patients, sufficient confirmation of equal clinical effectiveness and safety is …
Evaluation of Apixaban safety and effectiveness in morbidly obese patients with atrial fibrillation: a retrospective cohort study
Background The benefit of apixaban to reduce stroke risk in morbidly obese patients with
nonvalvular atrial fibrillation (AF) is still undetermined. The International Society of …
nonvalvular atrial fibrillation (AF) is still undetermined. The International Society of …
Effectiveness and safety of rivaroxaban versus warfarin among nonvalvular atrial fibrillation patients with obesity and polypharmacy
MJ Alberts, J He, A Kharat, V Ashton - American Journal of Cardiovascular …, 2022 - Springer
Background Current evidence suggests that rivaroxaban may be well tolerated and effective
in patients with nonvalvular atrial fibrillation (NVAF) and obesity; however, there is limited …
in patients with nonvalvular atrial fibrillation (NVAF) and obesity; however, there is limited …
Comparing the efficacy and safety of direct oral anticoagulants with warfarin in the morbidly obese population with atrial fibrillation
K Kido, S Ngorsuraches - Annals of Pharmacotherapy, 2019 - journals.sagepub.com
Background: The International Society of Thrombosis and Haemostasis recommends
avoiding direct oral anticoagulants (DOACs) in morbidly obese patients with a body mass …
avoiding direct oral anticoagulants (DOACs) in morbidly obese patients with a body mass …
Comparative effectiveness and safety of direct oral anticoagulants in obese patients with atrial fibrillation
Background Unlike warfarin direct oral anticoagulants (DOACs) are administered in fixed
doses, which raises concerns of its effectiveness on larger patients. Data from randomized …
doses, which raises concerns of its effectiveness on larger patients. Data from randomized …
Direct oral anticoagulants versus warfarin in morbidly obese patients with nonvalvular atrial fibrillation: a systematic review and meta-analysis
Background: Direct oral anticoagulants (DOACs) have been increasingly preferred over
warfarin; however, The International Society of Thrombosis and Hemostasis recommended …
warfarin; however, The International Society of Thrombosis and Hemostasis recommended …
Effectiveness and safety of oral anticoagulants among NVAF patients with obesity: insights from the ARISTOPHANES study
S Deitelzweig, A Keshishian, A Kang… - Journal of clinical …, 2020 - mdpi.com
This ARISTOPHANES analysis examined stroke/systemic embolism (SE) and major
bleeding (MB) among a subgroup of nonvalvular atrial fibrillation (NVAF) patients with …
bleeding (MB) among a subgroup of nonvalvular atrial fibrillation (NVAF) patients with …