Trauma-induced hemorrhage is a leading cause of disability and death due, in part, to
impaired perfusion and oxygenation of the brain. It is unknown if cerebrovascular responses …

Lower body negative pressure (LBNP) elicits central hypovolemia, and it has been used to
simulate the cardiovascular and cerebrovascular responses to hemorrhage in humans …

Tolerance to central hypovolemia is highly variable, and accumulating evidence suggests
that protection of anterior cerebral blood flow (CBF) is not an underlying mechanism. We …

Hemorrhage is a leading cause of potentially preventable death in both civilian and military
trauma settings. Lower body negative pressure (LBNP) is a validated, non-invasive, and …

The ability to maintain adequate cerebral blood flow and oxygenation determines tolerance
to central hypovolemia. We tested the hypothesis that acute hypoxemia during simulated …

Reductions in cerebral oxygen saturation (ScO2) measured by near infra-red spectroscopy
have been found during compensated hypovolemia in the lower body negative pressure …

During cerebral hypoperfusion induced by lower body negative pressure (LBNP), cerebral
tissue oxygenation is protected with oscillatory arterial pressure and cerebral blood flow at …

We examined the impact of progressive hypotension with and without hypocapnia on
regional extracranial cerebral blood flow (CBF) and intracranial velocities. Participants …

Supplemental oxygen is widely administered in trauma patients, often leading to hyperoxia.
However, the clinical evidence for providing supplemental oxygen in all trauma patients is …

Central hypovolemia elicited by application of lower body negative pressure (LBNP) has
been used extensively to simulate hemorrhage in human subjects. Traditional LBNP …