Autoimmune Diabetes and Transplantation Tolerance Induced by Costimulation Blockade
in NOD Mice: a Dissertation Page 1 University of Massachusetts Medical School …

A protocol consisting of a single donor-specific transfusion (DST) plus a brief course of anti-
CD154 monoclonal antibody (anti-CD40 ligand mAb) induces permanent islet allograft …

OBJECTIVE—NOD mice model human type 1 diabetes and are used to investigate
tolerance induction protocols for islet transplantation in a setting of autoimmunity. However …

Recent advances in islet transplantation have enabled physicians to cure type 1
autoimmune diabetes, but at the cost of lifelong immunosuppression with its attendant side …

Abstract Studying Type 1 Diabetes (T1D) in the nonobese diabetic (NOD) mouse model can
be cumbersome as onset of disease does not usually occur naturally prior to the age of 12 …

The concept of immunological tolerance is central to our understanding of type 1 diabetes
and the development of strategies for its prediction, prevention, and cure. Tolerance simply …

The loss of self-tolerance leading to autoimmune type 1 diabetes in the NOD mouse model
involves at least 19 genetic loci. In addition to their genetic defects in self-tolerance, NOD …

Curing type 1 diabetes by islet transplantation requires overcoming both allorejection and
recurrent autoimmunity. This has been achieved with systemic immunosuppression, but …

Background. Successful islet transplantation in type 1 diabetes requires tolerance induction
of both allo-and autoreactive T-cell responses. Monoclonal antibodies targeting the CD4 …

Type 1 Diabetes (T1D) is an autoimmune disease characterized by destruction of the
pancreatic beta cells by autoreactive lymphocytes. While autoreactive CD8+ T cells, CD4+ T …