The immune system of mammals is a complex host defense entity to protect the organism
against pathogens such as viruses, bacteria, fungi, and parasites, which can cause severe …

The Myc interacting zinc finger protein 1 (Miz-1) is a BTB/POZ domain containing
transcription factor that can function as an activator or repressor depending on its binding …

B cell development requires the coordinated action of transcription factors and cytokines, in
particular interleukin-7 (IL-7). We report that mice lacking the POZ (Poxvirus and zinc finger) …

Background Thymocyte expressed molecule involved in selection 1 (Themis1, SwissProt
accession number Q8BGW0) is the recently characterised founder member of a novel family …

Hematopoietic stem cells (HSC) are tasked with generating the entire blood cell repertoire
whilst maintaining their long-term functionality and are well-characterised in terms of their …

T cells originate from early T lineage precursors that have entered the thymus and
differentiate through well-defined steps. Mice deficient for the BTB/POZ domain of zinc finger …

As surveillance cells and phagocytes of the innate immune system, macrophages play a
vital role in the detection and destruction of harmful microorganisms, activation of …

Microbial components and the endogenous molecules released from damaged cells can
stimulate germ-line-encoded pattern recognition receptors (PRRs) to transduce signals to …

The microphthalmia-associated transcription factor family (MiT family) proteins are
evolutionarily conserved transcription factors that perform many essential biological …

ABSTRACT B cells constitute an important part of the adaptive immune system and produce
antibodies, which protect organism against infectious agents. Recognition of the antigen by …