We aimed to explore associations of several single nucleotide polymorphisms (SNPs)
detected by genome-wide association studies in uromodulin (UMOD) gene with phenotypes …

Background In recent genetic association studies, common variants including rs12917707 in
the UMOD locus have shown strong evidence of association with eGFR, prevalent and …

Common variants in the region of the UMOD gene, which encodes uromodulin (Tamm-
Horsfall protein), associate with chronic kidney disease (CKD) and estimated GFR (eGFR) …

Introduction Common variants in the UMOD gene are considered an evolutionary adaptation
against urinary tract infections (UTIs) and have been implicated in kidney stone formation …

Background A common variant of the UMOD gene was linked with prevalent chronic kidney
disease (CKD) in large, genomics consortia. One community-based study found that urine …

Background Several genome-wide association studies revealed that several variants of
UMOD gene were related to the estimated glomerular filtration rate (eGFR), CKD or …

Background Recent genome-wide association studies (GWAS) have identified common
variants in the UMOD region associated with kidney function and disease in the general …

UMOD variants associated with higher levels of urinary uromodulin (uUMOD) increase the
risk of chronic kidney disease (CKD) and hypertension. However, uUMOD levels also reflect …

Uromodulin (UMOD) is the most abundant protein secreted in urine and the mutated form of
the UMOD gene is associated with UMOD‑associated kidney disease (UAKD). Although …

Uromodulin is expressed exclusively in the thick ascending limb and is the most abundant
protein excreted in normal urine. Variants in UMOD, which encodes uromodulin, are …