The acquisition of an androgen-independent phenotype by prostate cancer cells is presently
a death sentence for patients. In order to have a realistic chance of changing this outcome …

Androgens are essential for the development, growth, and maintenance of the prostate.
They exert their effects via the intracellular androgen receptor (AR), which is a ligand …

Since the pioneering studies of Huggins nearly 60 years ago, it has been known that
prostate cancer cells, like certain normal prostate epithelial cells, can chronically depend on …

The androgen receptor (AR) signaling axis plays a critical role in the development, function
and homeostasis of the prostate. The classical action of AR is to regulate gene …

BACKGROUND Prostate cancer is the most commonly diagnosed cancer among men in
North America and is a leading cause of death. Standard treatments include androgen …

Benign prostatic hyperplasia (BPH) is an enlargement of the prostate gland that is frequently
found in aging men. Androgens are essential for the development and differentiated function …

This review is triggered by recent developments that offer new explanations for the
mechanism of progression of prostate cancer to androgen independence. Established and …

Androgen blockade is the mainstay of therapy in the clinical management of advanced
prostate cancer. Recent progress on two fronts–the development of newer xenograft and …

Since the effectiveness of androgen deprivation for treatment of advanced prostate cancer
was first demonstrated, prevention strategies and medical therapies for prostate cancer have …

Prostate epithelial differentiation is dictated by its surrounding stroma which determines
androgen induced growth responsiveness and expression of specific secretory proteins in …