Cancer and chronic infections often increase levels of the bioactive lipid, lysophosphatidic
acid (LPA), that we have demonstrated acts as an inhibitory ligand upon binding LPAR5 on …

Lysophosphatidic acid (LPA) is an endogenous bioactive lipid that is produced
extracellularly and signals to cells via cognate LPA receptors, which are G‐protein coupled …

CD8 T lymphocytes are able to eliminate nascent tumor cells through a process referred to
as immunosurveillance. However, multiple inhibitory mechanisms within the tumor …

Immunological tolerance has evolved to curtail immune responses against self-antigens and
prevent autoimmunity. One mechanism that contributes to immunological tolerance is the …

Persistent T cell antigen receptor (TCR) signaling by CD8 T cells is a feature of cancer and
chronic infections and results in the sustained expression of, and signaling by, inhibitory …

Lysophosphatidic acid (LPA) is a bioactive lipid which increases in concentration locally and
systemically across different cancer types. Yet, the exact mechanism (s) of how LPA affects …

Formation of immune synapses (IS) between T cells and APC requires multiple
rearrangements in the actin cytoskeleton and selective receptor accumulation in …

Monocytes and macrophages represent critical arms of the innate immune system and are
considered regulators and effectors of inflammation and the innate immune response …

T-cells need to be tightly regulated during their activation and effector phase to assure an
appropriate defence against cancer or pathogens and–vice versa–to avoid autoimmune …

Signaling through the T cell receptor (TCR) initiates adaptive immunity and its perturbation
may results in autoimmunity. The plasma membrane scaffolding protein LAT acts as a …