Involvement of brain-derived neurotrophic factor signaling in the pathogenesis of stress-related brain diseases

T Numakawa, R Kajihara - Frontiers in Molecular Neuroscience, 2023 - frontiersin.org
Neurotrophins including brain-derived neurotrophic factor, BDNF, have critical roles in
neuronal differentiation, cell survival, and synaptic function in the peripheral and central …

The role of neurotrophin signaling in age-related cognitive decline and cognitive diseases

T Numakawa, H Odaka - International Journal of Molecular Sciences, 2022 - mdpi.com
Neurotrophins are a family of secreted proteins expressed in the peripheral nervous system
and the central nervous system that support neuronal survival, synaptic plasticity, and …

Actions of brain-derived neurotrophin factor in the neurogenesis and neuronal function, and its involvement in the pathophysiology of brain diseases

T Numakawa, H Odaka, N Adachi - International journal of molecular …, 2018 - mdpi.com
It is well known that brain-derived neurotrophic factor, BDNF, has an important role in a
variety of neuronal aspects, such as differentiation, maturation, and synaptic function in the …

Brain-derived neurotropic factor in neurodegenerative disorders

AM Ibrahim, L Chauhan, A Bhardwaj, A Sharma… - Biomedicines, 2022 - mdpi.com
Globally, neurodegenerative diseases cause a significant degree of disability and distress.
Brain-derived neurotrophic factor (BDNF), primarily found in the brain, has a substantial role …

The role of brain derived neurotrophic factor in central nervous system

Y Li, F Li, D Qin, H Chen, J Wang, J Wang… - Frontiers in Aging …, 2022 - frontiersin.org
Brain derived neurotrophic factor (BDNF) has multiple biological functions which are
mediated by the activation of two receptors, tropomyosin receptor kinase B (TrkB) receptor …

[HTML][HTML] Functional interactions between steroid hormones and neurotrophin BDNF

T Numakawa, D Yokomaku, M Richards… - World Journal of …, 2010 - ncbi.nlm.nih.gov
Brain-derived neurotrophic factor (BDNF), a critical neurotrophin, regulates many neuronal
aspects including cell differentiation, cell survival, neurotransmission, and synaptic plasticity …

TrkB/BDNF signaling pathway and its small molecular agonists in CNS injury

Y Wang, J Liang, B Xu, J Yang, Z Wu, L Cheng - Life Sciences, 2023 - Elsevier
As one of the most prevalent neurotrophic factors in the central nervous system (CNS), brain-
derived neurotrophic factor (BDNF) plays a significant role in CNS injury by binding to its …

Neurotrophins and other growth factors in the pathogenesis of Alzheimer's disease

T Numakawa, R Kajihara - Life, 2023 - mdpi.com
The involvement of the changed expression/function of neurotrophic factors in the
pathogenesis of neurodegenerative diseases, including Alzheimer's disease (AD), has been …

Neurotrophin signalling: novel insights into mechanisms and pathophysiology

M Mitre, A Mariga, MV Chao - Clinical science, 2017 - portlandpress.com
Neurotrophins, such as brain-derived neurotrophic factor (BDNF), are prominent regulators
of neuronal survival, growth and differentiation during development. While trophic factors are …

Recent advances on the role of brain-derived neurotrophic factor (BDNF) in neurodegenerative diseases

KF Azman, R Zakaria - International journal of molecular sciences, 2022 - mdpi.com
Neurotrophins, such as brain-derived neurotrophic factor (BDNF), are essential for neuronal
survival and growth. The signaling cascades initiated by BDNF and its receptor are the key …