Conjugation of ubiquitin onto proteins generates a degradation signal or exerts degradation-
independent regulatory functions. Ubiquitylation is governed by the antagonistic action of …

Protein homeostasis is essential for cellular function, organismal growth and viability.
Damaged and aggregated proteins are turned over by two major proteolytic routes of the …

The ubiquitin/proteasome system (UPS) regulates the turnover of improperly folded and
damaged proteins to maintain protein homeostasis (proteostasis), cellular function, and …

Ubiquitylation, a widespread and important posttranslational modification of eukaryotic
proteins, regulates a multitude of critical cellular processes, both in normal and pathological …

Ubiquitination is a posttranslational modification characterized by the covalent attachment of
ubiquitin molecules to protein substrates. The ubiquitination modification process is …

Ubiquitination is a post-translational modification that generally directs proteins for
degradation by the proteasome or by lysosomes. However, ubiquitination has been …

In eukaryotic cells, proteome remodeling is mediated by the ubiquitin–proteasome system,
which regulates protein degradation, trafficking, and signaling events in the cell. Interplay …

The Ubiquitin (Ub) system coordinates vital cellular processes by controlling lifetime,
signaling, and binding properties of proteins. Ub serves as a multivalent protein tag that is …

Cellular differentiation, developmental processes, and environmental factors challenge the
integrity of the proteome in every eukaryotic cell. The maintenance of protein homeostasis …

Protein ubiquitylation regulates numerous pathways, and the diverse information encoded
by various forms of ubiquitylation is known as the ubiquitin code. Recent studies revealed …